GSM1586025[Accession] - GEO DataSets

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Items: 4

Select item 2000651611.

Mediator kinase inhibition further activates super-enhancer-associated genes in AML

(Submitter supplied) Super-enhancers (SEs), which are composed of large clusters of enhancers densely loaded with the Mediator complex, transcription factors and chromatin regulators, drive high expression of genes implicated in cell identity and disease, such as lineage-controlling transcription factors and oncogenes. BRD4 and CDK7 are positive regulators of SE-mediated transcription. By contrast, negative regulators of SE-associated genes have not been well described. more...

Organism:: Homo sapiens

Type:: Expression profiling by array; Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

5 related Platforms
89 Samples

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Accession:: GSE65161

ID:: 200065161

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000650302.

Effect in HCT116 cells of 3hr cortistatin A treatment on gene expression.

(Submitter supplied) We characterized the marine natural product cortistatin A (CA) as an inhibitor of CDK8 to determine whether pharmacologic inhibition of CDK8 regulates super-enhancer function and inhibits AML proliferation. In this series, we examine the transcriptional effect on insensitive HCT116 cells of 3hrs exposure to CA.