GSM5342250[Accession] - GEO DataSets

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Items: 4

Select item 2002313201.

Specification of a rostro-caudal axis in cortical assembloids through a polarized source of FGF8

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24676 GPL18573 GPL16791
46 Samples

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Series

Accession:: GSE231320

ID:: 200231320

Select item 2001755922.

Local source of FGF8 specifies a fronto-temporal axis in engineered human brain organoids (PolarOids)

(Submitter supplied) The establishment of the fronto-temporal axis in the developing human cortex is achieved by temporary signaling activity coming from secondary organizers. However, studying this process remains challenging due to the limited access to fetal material and inaccuracy of animal models in mimicking human-specific aspects. Although human brain organoids provide a potential solution to study this, their lack of axial organization does not supply the appropriate positional information needed to recapitulate detailed patterning processes in situ. more...