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Items: 3

1.

A Hybrid Mechanism of Action for BCL6 in B Cells Defined by Formation of Functionally Distinct Complexes at Enhancers and Promoters

(Submitter supplied) BCL6 is crucial for B-cell activation and lymphomagenesis. We used integrative genomics to explore BCL6 mechanism in normal and malignant B-cells. Surprisingly, BCL6 assembled distinct complexes at enhancers vs. promoters. At enhancers BCL6 preferentially recruited SMRT, which mediated H3K27 deacetylation through HDAC3, antagonized p300 activity and repressed transcription, but without decommissioning enhancers. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL15433 GPL10999 GPL11154
46 Samples
Download data: BED, BW, TXT, WIG
Series
Accession:
GSE29282
ID:
200029282

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

2.

Illumina HiSeq 2000 (Homo sapiens)

Organism:
Homo sapiens
10400 Series
180082 Samples
Download data
Platform
Accession:
GPL11154
ID:
100011154

3.

OCI-LY1_siBCL6_24hrs_mRNAseq

Organism:
Homo sapiens
Source name:
Human DLBCL cell line
Platform:
GPL11154
Series:
GSE29282
Download data: BED
Sample
Accession:
GSM756310
ID:
300756310

SRA Run Selector

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db=gds|term=GSM756310[Accession]|query=1|qty=2|blobid=MCID_6643bab05f31ac4911936e0b|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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