GSM937868[Accession] - GEO DataSets

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Items: 4

Select item 2000382751.

ChIP-seq and RIP-seq for SCML2 and SCML2 mutants in 293T-REx and K562 cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Other; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
49 Samples

Download data: BW, WIG

Series

Accession:: GSE38275

ID:: 200038275

PubMed Full text in PMC Similar studies

Select item 2000382732.

ChIP-seq for SCML2 and SCML2 mutants in 293T-REx and K562 cells

(Submitter supplied) Polycomb repressive complex-1 (PRC1) is essential for the epigenetic regulation of gene expression. SCML2 is a mammalian homolog of Drosophila SCM, a Polycomb-group protein that associates with PRC1. Here, we show that SCML2A, an SCML2 isoform tightly associated to chromatin, contributes to PRC1 localization and also directly enforces repression of certain Polycomb target genes. SCML2A binds to PRC1 via its SPM domain and interacts with ncRNAs through a novel RNA-binding region (RBR). more...