GSM985101[Accession] - GEO DataSets

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Items: 4

Select item 2000401121.

Stochastic genome - nuclear lamina contacts are linked to histone H3K9 dimethylation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array; Expression profiling by high throughput sequencing

Platforms:: GPL11154 GPL10559
13 Samples

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Series

Accession:: GSE40112

ID:: 200040112

Select item 2000401112.

Stochastic genome - nuclear lamina contacts are linked to histone H3K9 dimethylation (RNA-seq data)

(Submitter supplied) The nuclear lamina (NL) interacts with hundreds of large genomic regions termed lamina-associated domains (LADs). The dynamics of these interactions and the relation to epigenetic modifications are poorly understood. We visualized the fate of LADs in single cells using a novel 'molecular contact memory' approach. In each interphase nucleus, only ~30% of LADs are positioned at the periphery; these LADs are in intermittent molecular contact with the NL but remain constrained to the periphery. more...