txid9615[Organism:noexp] - GEO DataSets

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Select item 2002665851.

Deconstruction of cellular dynamics after treatment of volumetric muscle loss injury with extracellular matrix

(Submitter supplied) Volumetric muscle loss (VML) is an acute loss of a critical volume of skeletal muscle that results in inflammation, fibrotic scarring in muscle tissue, and permanent muscle defects. The cellular and molecular processes that underlie fibrosis induced from VML injury need to be evaluated in larger animal models. Therefore, we used a canine model of VML alongisde treatment with an extracellular matrix (ECM) hydrogel. more...

Organism:: Canis lupus familiaris

Type:: Other

Platform:: GPL25760
17 Samples

Download data: RDS

Series

Accession:: GSE266585

ID:: 200266585

Select item 2002662342.

Stromal expression profiling reveals immune-driven adaption to malignancy in canine melanoma subtypes

(Submitter supplied) Canine mucosal melanoma (CMM) is the most common oral malignancy in dogs and exhibits significantly higher aggressiveness than its cutaneous counterpart (CCM), yet the reasons for this disparity remain unclear. The influence of cancer-associated stroma (CAS) on tumour progression is well-recognized, but a detailed understanding of CAS in canine melanoma is missing. To comprehensively assess stromal reprogramming in canine melanoma, we analysed CAS from 21 CMM, 14 CCM and normal stroma from 10 skin and 9 oral mucosa samples by laser-capture microdissection followed by RNA sequencing. more...

Organism:: Canis lupus familiaris

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25760
54 Samples

Download data: XLSX

Series

Accession:: GSE266234

ID:: 200266234

Select item 2002540053.

Single-Cell RNA Sequencing Investigation of the Duodenal Mucosa in Canine Chronic Inflammatory Enteropathy and Health

(Submitter supplied) We used single-cell RNA sequencing to characterize the heterogeneity duodenal tissue in healthy and chronic inflammatory enteropathy (CIE) affected dogs.

Organism:: Canis lupus familiaris

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25760
7 Samples

Download data: MTX, TSV

Series

Accession:: GSE254005

ID:: 200254005

Select item 2002632814.

Spatial gene expression of canine veins during carotid-cartoid vein bypass implantation

(Submitter supplied) Vein graft failure (VGF) following cardiovascular bypass surgery results in significant patient morbidity and cost to the healthcare system. Vein graft injury can occur during autogenous vein harvest and preparation, as well as after implantation into the arterial system, leading to the development of intimal hyperplasia, vein graft stenosis, and, ultimately, bypass graft failure. While previous studies have identified maladaptive pathways that occur shortly after implantation, the specific signaling pathways that occur during vein graft preparation are not well defined and may result in a cumulative impact on VGF. more...

Organism:: Canis lupus familiaris

Type:: Other

Platform:: GPL25760
8 Samples

Download data: MTX, TAR, TSV

Series

Accession:: GSE263281

ID:: 200263281

Select item 2002632805.

Single-nuclei expression of canine veins during carotid-cartoid vein bypass implantation

Organism:: Canis lupus familiaris

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25760
5 Samples

Download data: MTX, TSV

Series

Accession:: GSE263280

ID:: 200263280

Select item 2002676246.

Establishment and characterization of six canine hepatocellular carcinoma cell lines (Transcriptional changes induced by drug treatment with toceranib or sorafenib)

(Submitter supplied) Hepatocellular carcinoma (HCC) is the most common malignant liver tumor in dogs. Although surgical resection is a major treatment option for canine HCC, there are no distinct strategies for unresectable tumor subtypes or adjuvant chemotherapy for tumors with positive margins. We aimed to establish and characterize novel HCC cell lines from canine patients. The cellular morphology, general growth features and tumorigenicity of the established cell lines were evaluated. more...

Organism:: Canis lupus familiaris

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25760
16 Samples

Download data: TXT

Series

Accession:: GSE267624

ID:: 200267624

Select item 2002674027.

Canid alphaherpesvirus 1 infection affects the gene expression and secretome profile of canine adipose-derived mesenchymal stem cells in vitro

(Submitter supplied) Canine adipose -derived mesenchymal stem cells (cAD-MSCs) demonstrate promising tissue repair and regeneration capabilities. However, the procurement and preservation of these cells or their secreted factors for therapeutic applications pose a risk of viral contamination, and the consequences on cAD-MSCs remain unexplored. Consequently, this research sought to assess the impact of Canid alphaherpesvirus 1 on the functional attributes of cAD-MSCs, including gene expression profiles and secretome composition. more...

Organism:: Canis lupus familiaris

Type:: Expression profiling by RT-PCR

Platform:: GPL34182
24 Samples

Download data: XLS

Series

Accession:: GSE267402

ID:: 200267402

Select item 2002326428.

Altered Chromatin State Drives Hypersocial Behaviors in Canids

(Submitter supplied) Polymorphic transposable elements found in regulatory sequences can impact the associated transactional modules. We investigated such molecular alterations for these elements in the dog genome that evolved from directional selection during domestication. We find that the polymorphic element in canine GTF2I intron 17 is associated with altered looping, and hence distinct cis-regulatory landscapes. We report supporting evidence of an E2F1-DNA binding peak concordant with the altered loop and higher expression of GTF2I exon 18. more...

Organism:: Canis lupus familiaris

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL25760
18 Samples

Download data: BED, BW

Series

Accession:: GSE232642

ID:: 200232642

Select item 2002626259.

An optimized workflow for transcriptomic analysis from archival paraformaldehyde-fixed retinal tissues collected by laser capture microdissection

(Submitter supplied) RNA sequencing (RNA-seq) coupled with laser capture microdissection (LCM) is a powerful tool for transcriptomic analysis in unfixed fresh-frozen tissues. Fixation of ocular tissues for immunohistochemistry commonly involves the use of paraformaldehyde (PFA) followed by embedding in Optimal Cutting Temperature (OCT) medium for long-term cryopreservation. However, the quality of RNA derived from such archival PFA-fixed/OCT-embedded samples is often compromised, limiting its suitability for transcriptomic studies. more...

Organism:: Canis lupus familiaris

Type:: Expression profiling by high throughput sequencing

Platform:: GPL33053
8 Samples

Download data: TXT

Series

Accession:: GSE262625

ID:: 200262625

Select item 20016448810.

Two distinct Epithelial to Mesenchymal Transition Programmes Control Invasion and Inflammation in Segregated Tumour Cell Populations

(Submitter supplied) The goal of this study is to analyze mRNA transcriptional changes associated with partial and full EMTs undergone by kidney epithelial dog MDCK cells upon treatment with TGFb.

Organism:: Canis lupus familiaris

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24229
24 Samples

Download data: TXT

Series

Accession:: GSE164488

ID:: 200164488

SRA Run Selector

Select item 20023599811.

Notch3 drives meningioma tumorigenesis and resistance to radiotherapy

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Canis lupus familiaris

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL25760 GPL24676
29 Samples

Download data: TAR

Series

Accession:: GSE235998

ID:: 200235998

Select item 20022472312.

Single-cell RNA sequencing of canine meningiomas

(Submitter supplied) We report single-cell RNA sequencing of 54,607 cells from 3 canine meningioma and 2 canine dura samples.

Organism:: Canis lupus familiaris

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25760
5 Samples

Download data: TAR

Series

Accession:: GSE224723

ID:: 200224723

Select item 20024077613.

Extracellular vesicles from epicardial fat mediate long-distance heart-brain communication and promote atrial fibrillation associated cognitive impairment (EAT exosomal miRNA-seq and hippocampal mRNA-seq)

(Submitter supplied) 2 weeks of rapid atrial pacing increased the release of epicardial adipose tissue (EAT) exosomes. The red fluorescence of Ad-CD63-RFP traces the increase of EAT exosomes in the canine hippocampus. RNA Sequencing showed that the differentially expressed genes of cfa-miR-22e in EAT exosomes were significantly increased, and its target gene of IL33 was down-regulated in the hippocampus. Exosomes secreted by EAT in AF model canine penetrate the BBB, and activate hippocampal microglia through cfa-miR-22e/IL33 signaling pathway, which may be related to the increased risk of cognitive impairment in AF.

Organism:: Canis lupus familiaris

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platform:: GPL33670
12 Samples

Download data: FA, TXT

Series

Accession:: GSE240776

ID:: 200240776

Select item 20023027114.

Establishment and characterization of canine mammary gland tumor(MGT) cell lines

(Submitter supplied) To investigate the canine mammary gland tumor, we established 8 cell lines We then performed gene expression profiling analysis using data obtained from RNA-seq of 10 different cells.

Organism:: Canis lupus familiaris

Type:: Expression profiling by high throughput sequencing

Platform:: GPL33357
10 Samples

Download data: CSV

Series

Accession:: GSE230271

ID:: 200230271

Select item 20026139515.

Immuno-Oncologic Profiling by Stage-Dependent Transcriptome and Proteome Analyses of Spontaneously Regressing Canine Cutaneous Histiocytoma [NanoString]

(Submitter supplied) Canine cutaneous histiocytoma (CCH) is a tumor originating from dermal Langerhans cells, especially affecting young dogs. The common spontaneous regression of CCH makes it an interesting model in comparative oncology research. Previous studies have indicated that anti-tumor immune responses may be involved but details remain speculative to date. Here, we asked which specific immuno-oncological dynamics underlie spontaneous regression of CCH on mRNA and protein levels. more...

Organism:: Canis lupus familiaris

Type:: Expression profiling by array

Platform:: GPL32796
21 Samples

Download data: RCC, TXT

Series

Accession:: GSE261395

ID:: 200261395

Analyze with GEO2R

Select item 20026138716.

Immuno-Oncologic Profiling by Stage-Dependent Transcriptome and Proteome Analyses of Spontaneously Regressing Canine Cutaneous Histiocytoma

Organism:: Canis lupus familiaris

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21400
21 Samples

Download data: TSV

Series

Accession:: GSE261387

ID:: 200261387

Select item 20024735517.

Targeting Osteosarcoma with Canine B7-H3 CAR T Cells and Impact of CXCR2 Co-Expression on Functional Activity

(Submitter supplied) Abstract. The use of large animal spontaneous models of solid cancers, such as dogs with osteosarcoma (OS), can help develop new cancer immunotherapy approaches, including chimeric antigen receptor (CAR) T cells. Therefore, the goal of the present study was to generate canine CAR T cells targeting the B7-H3 (CD276) co-stimulatory molecule overexpressed by several solid cancers, including OS and glioma in both humans and dogs, and to assess their ability to recognize B7-H3 expressed by canine OS cell lines or by canine tumors in xenograft models. more...

Organism:: Canis lupus familiaris

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24229
9 Samples

Download data: TXT

Series

Accession:: GSE247355

ID:: 200247355

PubMed Full text in PMC Similar studies

Select item 20025247018.

Single-cell RNA sequencing reveals the cellular and molecular heterogeneity of treatment-naïve primary osteosarcoma in dogs

(Submitter supplied) We used single-cell RNA sequencing to characterize the heterogeneity of canine osteosarcoma (OS) tumors.

Organism:: Canis lupus familiaris

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25760
8 Samples

Download data: MTX, TSV

Series

Accession:: GSE252470

ID:: 200252470

Select item 20026202219.

Strong Correlation of Gene Counts and Differentially Expressed Genes between a 3′ RNA-Seq and RNA Hybridisation Platform from Canine Archival Tissue [RNA-Seq]

(Submitter supplied) 3' RNA-Seq and direct RNA hybridisation are conceptually different approaches for high throughput transcriptome analysis. The former generates next-generation sequencing libraries by targeting and amplifying 3'-end sequences of 60 to 80 nucleotides in length, whereas the latter quantifies transcripts of 800 pre-selected genes. Since both methods are applicable to short mRNA fragments, they are thought to allow for transcriptome analyses from formalin-fixed, paraffin-embedded (FFPE) archival tissue containing partially degraded RNA. more...