GEO DataSets

Examination of spleen and thymus of type 1 diabetes nonobese diabetic (NOD) mouse, four NOD-derived diabetes-resistant congenic strains and two nondiabetic control strains.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 disease state, 7 strain, 2 tissue sets

Platform:

GPL24

Series:

GSE11

28 Samples

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(Submitter supplied) We used high density oligonucleotide arrays to measure the relative expression levels of >39,000 genes and ESTs in the NOD mouse (a murine model of T1D and other autoimmune conditions), four NOD-derived diabetes resistant congenic strains and two nondiabetic control strains. Owing to the importance of T cells in the development of T1D we decided to target two organs, the spleen and thymus. We profiled gene expression in thymi from four week old female mice and spleens from three month old female mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS10

Platform:

GPL24

28 Samples

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(Submitter supplied) Custom Affymetrix GeneChip designed by Eos Biotechnology Inc. to measure the expression of a large number of genes or ESTs on a single array. This is achieved by choosing those probes from within each set of 20 Affymetrix perfect match probes that show the least random fluctuation relative to the perceived specific hybridization over a wide ranging set of samples (Glynne et al. 2000). Experiments undertaken by Eos have revealed that the mismatch probes do not increase sensitivity or reproducibility (RJG and GG unpublished data). more...

Organism:

Mus musculus

1 DataSet

3 Series

28 Samples

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(Submitter supplied) Analysis of gene expression levels in ex-vivo and p79-stimulated splenic CD4+ T cells.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL14828

12 Samples

Download data: TXT

(Submitter supplied) CD11b+ CD11c- cells were isolated by cell sorting from the spleens of NOD and NOD.Idd3 mice. Cells were then either unstimulated or stimulated with peptidoglycan (5ug/ml) for 4 hours at 37 degrees prior to RNA extraction. Peptidoglycan was chosen as a stimulus due to its know ability to stimulate CD11b+ cells through Toll-like receptor 2 and our previous data showing biological differences between NOD and NOD.Idd3-derived CD11b+CD11c- cells after stimulation with peptidoglycan.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

8 Samples

Download data: CEL

(Submitter supplied) Regulatory T lymphocytes expressing the transcription factor Foxp3 (Treg) play an important role in the prevention of autoimmune diseases and other immunopathologies. Aberrations in Treg-mediated immunosuppression are therefore thought to be involved in the development of autoimmune pathologies but few have been documented. Recent reports indicated a central role for Treg developing during the neonatal period in the prevention of autoimmune pathology. more...

Organism:

Mus musculus

Type:

Genome variation profiling by array

Platform:

GPL34100

96 Samples

Download data: IDAT