Similar studies for GEO DataSets (Select 200008325) - GEO DataSets

Select item 2000083251.

Cytotoxic activity of HTI-286 in prostate cancer

(Submitter supplied) HTI-286, an analogue of hemiasterlin, interferes with microtubule dynamics and circumvents transport-based resistance to taxanes. In this study we evaluate the inhibitory effects of HTI-286 on human prostate cancer growth in vitro and in different in vivo models. The results show that HTI-286 is a potent inhibitor of proliferation and induced marked increases in apoptotic rates in all cell lines tested. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2971
Platform:: GPL3877
12 Samples

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Series

Accession:: GSE8325

ID:: 200008325

Select item 29712.

Hemiasterlin analog HTI-286 effect on docetaxel-resistant prostate cancer cell line

Analysis of prostate cancer LNCaP cells treated with the chemotherapeutic agent docetaxel or the hemiasterlin analog HTI-286. Like docetaxel, HTI-286 disrupts microtubule dynamics. But unlike docetaxel, HT-286 exhibits reduced multidrug resistance.

Organism:: Homo sapiens

Type:: Expression profiling by array, log2 ratio, 2 agent sets

Platform:: GPL3877
Series:: GSE8325
12 Samples

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DataSet

Accession:: GDS2971

ID:: 2971

Select item 2000591063.

Effect of AZD1208 on gene expression in recurrent resistant Myc-CaP tumors grown in castrated mice.

(Submitter supplied) AZD1208 is a novel PIM kinase inhibitor that we have shown inhibits tumorigenesis in tissue recombination models, Myc-CaP allograft models, and human prostate cancer xenografts. We sought to determine the intracellular pathways that are responsible for the anti-tumor effect. To this end we used the tissue recombination protocol to implant MYCCaP cells into castrated mice. MYCCaP cells are an androgen-dependent mouse cell line that overexpresses the oncogene MYC. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
9 Samples

Download data: CEL

Series

Accession:: GSE59106

ID:: 200059106

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000334554.

Expression data from docetaxel-resistant prostate cancer cell lines

(Submitter supplied) Docetaxel-based chemotherapy is the standard first-line therapy in metastatic castration-resistant prostate cancer. However, most patients eventually develop resistance to this treatment. The aim of the study was to identify key molecular genes and networks associated with docetaxel resistance in 2 models of docetaxel-resistant castration-resistant prostate cancer cell lines.

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3973
Platform:: GPL570
12 Samples

Download data: CEL

Series

Accession:: GSE33455

ID:: 200033455

Select item 39735.

Docetaxel resistant prostate cancer cell line

Analysis of prostate cancer cell lines resistant to docetaxel chemotherapy, DU-145R and PC-3R, which were derived from cell lines DU-145 and PC-3, respectively. Results provide insight into the molecular mechanisms underlying docetaxel resistance.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 4 cell line sets

Platform:: GPL570
Series:: GSE33455
12 Samples

Download data: CEL

DataSet

Accession:: GDS3973

ID:: 3973

Select item 2000548206.

Strigolactone analogs induce apoptosis through activation of p38 and the stress response pathway in cancer cell lines and in conditionally reprogrammed primary prostate cancer cells

(Submitter supplied) Strigolactones are a novel class of plant hormones produced in roots and regulate shoot and root development. We have previously shown that synthetic strigolactone analogues potently inhibit growth of breast cancer cells and breast cancer stem cells. Here we show that strigolactone analogues inhibit the growth and survival of an array of cancer-derived cell lines representing solid and non-solid cancer cells including: prostate, colon, lung, melanoma, osteosarcoma and leukemic cell lines, while normal cells were minimally affected. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Datasets:: GDS5221 GDS5222
Platform:: GPL10558
12 Samples

Download data: TXT

Series

Accession:: GSE54820

ID:: 200054820

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 52227.

U2OS osteosarcoma cell line response to strigolactone analogs ST362 and MEB55: 24 hours

Analysis of U2OS cells treated with strigolactone (SL) analog ST362 or MEB55 for 24hr. SL is a plant hormone. SL analogs potently inhibit growth of breast cancer cells. Results provide insight into molecular mechanisms underlying the anti-tumorigenic effects of SL analogs towards cancer cells.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 3 agent sets

Platform:: GPL10558
Series:: GSE54820
6 Samples

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DataSet

Accession:: GDS5222

ID:: 5222

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 52218.

U2OS osteosarcoma cell line response to strigolactone analogs ST362 and MEB55: 6 hours

Analysis of U2OS cells treated with strigolactone (SL) analog ST362 or MEB55 for 6hr. SL is a plant hormone. SL analogs potently inhibit growth of breast cancer cells. Results provide insight into molecular mechanisms underlying the anti-tumorigenic effects of SL analogs towards cancer cells.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 3 agent sets

Platform:: GPL10558
Series:: GSE54820
6 Samples

Download data

DataSet

Accession:: GDS5221

ID:: 5221

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2001523129.

Effect of bone marrow microenvironment on the sensitivity of breast cancer cells to antiestrogens

(Submitter supplied) Hormonal therapy (HT) inhibits the growth of hormone receptor-positive (HR+) breast (BrCa) and prostate (PrCa) cancers. HT resistance frequently develops within the complex metastatic microenvironment of the host-organ (often the bone), a setting poorly recapitulated in two-dimensional (2D) culture systems. To address this limitation, we cultured HR+ BrCa/PrCa spheroids and patient-derived organoids in 3D extracellular matrices (ECM) alone or together with bone marrow stromal cells (BMSCs). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
18 Samples

Download data: TXT

Series

Accession:: GSE152312

ID:: 200152312

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20009982010.

Effects of WCE herbal extract on hormone-refractory PC-3 tumors

(Submitter supplied) Purpose: Androgen-deprivation therapy is the standard treatment for prostate cancer but fails in hormone-refractory prostate cancer. The anti-inflammatory plant Wedelia chinensis is rich in luteolin, apigenin, and wedelolactone that act synergistically to suppress androgen receptor activity in prostate cancer. Here, we evaluated the systemic antitumor effects of a standardized and effect-optimized Wedelia chinensis herbal extract (WCE) on hormone-refractory prostate cancer. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL15456
6 Samples

Download data: TXT

Series

Accession:: GSE99820

ID:: 200099820

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20018037311.

NCOR2 controls androgen deprivation therapy failure in advanced prostate cancer through re-wiring of the onco-epigenome [RNA-seq]

(Submitter supplied) NCOR2 is frequently and significantly mutated in late stage androgen deprivation therapy resistant prostate cancer (ADT-RPCa). NCOR2 has been characterized as a transcriptional corepressor and has mechanistic links to DNA methylation, but its global functions and overall contributions to PCa progression remain enigmatic. We mapped the dihydrotestosterone (DHT) dependent and independent effects of NCOR2 on the transcriptome, cistrome and DNA methylome in androgen sensitive (AS) and ADT-RPCa cells using the isogenic LNCaP and LNCaP-C4-2 (C4-2) cell models and the CWR22 xenograft model of ADT-RPCa.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
36 Samples

Download data: CSV

Series

Accession:: GSE180373

ID:: 200180373

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20018037212.

NCOR2 controls androgen deprivation therapy failure in advanced prostate cancer through re-wiring of the onco-epigenome [ChIP-seq]

(Submitter supplied) NCOR2 is frequently and significantly mutated in late stage androgen deprivation therapy resistant prostate cancer (ADT-RPCa). NCOR2 has been characterized as a transcriptional corepressor and has mechanistic links to DNA methylation, but its global functions and overall contributions to PCa progression remain enigmatic. We mapped the dihydrotestosterone (DHT) dependent and independent effects of NCOR2 on the transcriptome, cistrome and DNA methylome in androgen sensitive (AS) and ADT-RPCa cells using the isogenic LNCaP and LNCaP-C4-2 (C4-2) cell models and the CWR22 xenograft model of ADT-RPCa.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
24 Samples

Download data: BED

Series

Accession:: GSE180372

ID:: 200180372

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20017913313.

NCOR2 controls androgen deprivation therapy failure in advanced prostate cancer through re-wiring of the onco-epigenome [CWR22 xenograft]

(Submitter supplied) NCOR2 is frequently and significantly mutated in late stage androgen deprivation therapy resistant prostate cancer (ADT-RPCa). NCOR2 has been characterized as a transcriptional corepressor and has mechanistic links to DNA methylation, but its global functions and overall contributions to PCa progression remain enigmatic. We mapped the dihydrotestosterone (DHT) dependent and independent effects of NCOR2 on the transcriptome, cistrome and DNA methylome in androgen sensitive (AS) and ADT-RPCa cells using the isogenic LNCaP and LNCaP-C4-2 (C4-2) cell models and the CWR22 xenograft model of ADT-RPCa.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
33 Samples

Download data: CSV

Series

Accession:: GSE179133

ID:: 200179133

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20017882014.

NCOR2 controls androgen deprivation therapy failure in advanced prostate cancer through re-wiring of the onco-epigenome

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

4 related Platforms
161 Samples

Download data: IDAT

Series

Accession:: GSE178820

ID:: 200178820

PubMed Full text in PMC Similar studies

Select item 20017881915.

NCOR2 controls androgen deprivation therapy failure in advanced prostate cancer through re-wiring of the onco-epigenome [CWR22_EPIC]

(Submitter supplied) NCOR2 is frequently and significantly mutated in late stage androgen deprivation therapy resistant prostate cancer (ADT-RPCa). NCOR2 has been characterized as a transcriptional corepressor and has mechanistic links to DNA methylation, but its global functions and overall contributions to PCa progression remain enigmatic. We mapped the dihydrotestosterone (DHT) dependent and independent effects of NCOR2 on the transcriptome, cistrome and DNA methylome in androgen sensitive (AS) and ADT-RPCa cells using the isogenic LNCaP and LNCaP-C4-2 (C4-2) cell models and the CWR22 xenograft model of ADT-RPCa.

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL23976
32 Samples

Download data: CSV, IDAT

Series

Accession:: GSE178819

ID:: 200178819

PubMed Full text in PMC Similar studies

Select item 20017881816.

NCOR2 controls androgen deprivation therapy failure in advanced prostate cancer through re-wiring of the onco-epigenome [CellLine_EPIC]

(Submitter supplied) NCOR2 is frequently and significantly mutated in late stage androgen deprivation therapy resistant prostate cancer (ADT-RPCa). NCOR2 has been characterized as a transcriptional corepressor and has mechanistic links to DNA methylation, but its global functions and overall contributions to PCa progression remain enigmatic. We mapped the dihydrotestosterone (DHT) dependent and independent effects of NCOR2 on the transcriptome, cistrome and DNA methylome in androgen sensitive (AS) and ADT-RPCa cells using the isogenic LNCaP and LNCaP-C4-2 (C4-2) cell models and the CWR22 xenograft model of ADT-RPCa.

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL23976
36 Samples

Download data: CSV, IDAT

Series

Accession:: GSE178818

ID:: 200178818

PubMed Full text in PMC Similar studies

Select item 20015911617.

Regulation of anti-tumorigenic pathways by the combinatory treatment of calcitriol and TGF-β in PC-3 cells

(Submitter supplied) Calcitriol and transforming growth factors beta (TGF-β) are involved in several biological pathways such as cell proliferation, differentiation, migration and invasion. Their cellular effects could be similar or opposite depending on the genetic target, cell type and context. Despite the reported association of calcitriol deficiency and disruption of the TGF-β pathway in prostate cancer and the well-known independent effects of calcitriol and TGF-βs on cancer cells, there is limited information regarding the cellular effects of calcitriol and TGF-β in combination. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL23126
8 Samples

Download data: CEL

Series

Accession:: GSE159116

ID:: 200159116

Select item 20009381218.

LuCaP prostate cancer patient-derived xenografts reflect the molecular heterogeneity of advanced disease and serve as models for evaluating cancer therapeutics [CGH]

(Submitter supplied) In order to advance our understanding of prostate cancer biology and identify new effective treatments we have established and characterized multiple advanced prostate cancer patient-derived xenografts that mimic well the disease in patients.

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL21289
33 Samples

Download data: TXT

Series

Accession:: GSE93812

ID:: 200093812

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20009380919.

LuCaP prostate cancer patient-derived xenografts reflect the molecular heterogeneity of advanced disease and serve as models for evaluating cancer therapeutics [GE]

(Submitter supplied) In order to advance our understanding of prostate cancer biology and identify new effective treatments we have established and characterized multiple advanced prostate cancer patient-derived xenografts that mimic well the disease in patients.