Similar studies for GEO DataSets (Select 200046237) - GEO DataSets

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Items: 4

Select item 2000462371.

NR2C/F orphan receptors induce telomere-genome rearrangements in ALT

(Submitter supplied) Most sarcomas have complex karyotype and are characterized by multiple chromosomal rearrangements. Moreover, sarcomas very frequently maintain their telomeres by recombination in the process called Alternative Lengthening of Telomeres (ALT) which enables their continuous growth and immortalization. Previously our group showed that orphan receptors bind specifically to the ALT telomeres and that their presence is important for the ALT mechanism. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
10 Samples

Download data: BED, BIGWIG

Series

Accession:: GSE46237

ID:: 200046237

PubMed Similar studies SRA Run Selector

Select item 2001172142.

ZBTB10 binds the telomeric variant repeat TTGGGG and interacts with TRF2

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL15520 GPL18573
26 Samples

Download data

Series

Accession:: GSE117214

ID:: 200117214

PubMed Full text in PMC Similar studies

Select item 2001172133.

ZBTB10 binds the telomeric variant repeat TTGGGG and interacts with TRF2 [DNA-Seq validation of KO]

(Submitter supplied) In order to investigate changes upon ZBTB10 depletion, we used CRISPR/Cas9 to induce a ZBTB10 knockout in HEK293 and U2OS cells.

Organism:: Homo sapiens

Type:: Other

Platform:: GPL15520
10 Samples

Download data: XLS

Series

Accession:: GSE117213

ID:: 200117213

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001172124.

ZBTB10 binds the telomeric variant repeat TTGGGG and interacts with TRF2 [RNA-Seq]

(Submitter supplied) To study if ZBTB10 influences gene expression, we used CRISPR/Cas9 knockout HEK293 and U2OS cells to compare transcript levels between WT and KO.