Similar studies for GEO DataSets (Select 200149298) - GEO DataSets

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Items: 20

Select item 2001492981.

Integrative molecular profiling of autoreactive CD4 T cells in autoimmune hepatitis

(Submitter supplied) Background & Aims: In most autoimmune disorders, crosstalk of B cells and CD4 T cells results in the accumulation of autoantibodies targeting specific self-antigen like the Soluble Liver Antigen (SLA or SepSecs) in autoimmune hepatitis (AIH). But the associated autoreactive CD4 T cells have not been characterized yet. Here we isolated and deeply characterized SLA-specific CD4 T cells in AIH patients. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21697
14 Samples

Download data: CSV, DOCX, XLSX

Series

Accession:: GSE149298

ID:: 200149298

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Select item 2001143572.

TLR9 Stimulation of Anergic HCV-Associated Clonal Memory B Cells Triggers Rheumatoid Factor Autoimmunity by the TNF-α Pathway

(Submitter supplied) Transcriptionnal analysis of pathogenic IgM Memory B cells stimulated or not with CpG from 3 differents HCV related Cryoglobulinemia.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
6 Samples

Download data: TXT

Series

Accession:: GSE114357

ID:: 200114357

Select item 2002294593.

Morphologic and molecular analysis of liver injury after SARS-CoV-2 vaccination reveals distinct characteristics

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL24676 GPL32271
92 Samples

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Series

Accession:: GSE229459

ID:: 200229459

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Select item 2002294244.

Morphologic and molecular analysis of liver injury after SARS-CoV-2 vaccination reveals distinct characteristics [TCR-seq, BCR-seq]

(Submitter supplied) Background and Aims: Liver injury after COVID-19 vaccination is very rare and shows clinical and histomorphological similarities with autoimmune hepatitis (AIH). Little is known about the pathophysiology of COVID-19 vaccine-induced liver injury (VILI) and its relationship to AIH. Therefore, we compared VILI with AIH. Methods: Formalin-fixed and paraffin-embedded liver biopsy samples from patients with VILI (n=6) and from patients with an initial diagnosis of AIH (n=9) were included. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL32271
32 Samples

Download data: XLSX

Series

Accession:: GSE229424

ID:: 200229424

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Select item 2002287795.

Morphologic and molecular analysis of liver injury after SARS-CoV-2 vaccination reveals distinct characteristics [RNA-seq]

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
60 Samples

Download data: XLSX

Series

Accession:: GSE228779

ID:: 200228779

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Select item 2001366426.

CXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
31 Samples

Download data: H5

Series

Accession:: GSE136642

ID:: 200136642

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Select item 2001366417.

CXCR5+PD-1+CD8+ T cells are a novel T helper cell sublineage and are negatively regulated by Stat5 [scRNA-Seq]

(Submitter supplied) Many autoimmune diseases are characterized by the production of autoantibodies. The current view is that CD4+ Tfh cells are the main subset regulating autoreactive B cells. Here, we discover a distinct novel CXCR5+PD1+ Tfh subset of CD8+ T cells whose development and function are negatively regulated by Stat5. These CD8+ Tfh cells regulate the GC B cell response and control autoantibody production. Deficiency of Stat5 in CD8+ T cells leads to an increase of CD8+ Tfh cells, resulting in the breakdown of B cell tolerance and autoantibody production. CD8+ Tfh share similar gene signatures with CD4+ Tfh and require CD40L/CD40 and TCR/MHCI interactions to deliver help to B cells. Our study highlights the diversity of follicular T cell subsets that contribute to the breakdown of B-cell tolerance

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
4 Samples

Download data: H5

Series

Accession:: GSE136641

ID:: 200136641

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Select item 2001366408.

CXCR5+PD-1+CD8+ T cells are a distinct sublineage of CD8+ Tfh cells and Stat5 suppresses the expression of the Tfh-specific genes in CXCR5+PD-1+CD8+ T cells [RNA-Seq]

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
27 Samples

Download data: GCT

Series

Accession:: GSE136640

ID:: 200136640

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Select item 2001372759.

FB5P-seq: FACS-based 5-prime end single-cell RNAseq for integrative analysis of transcriptome and antigen receptor repertoire in B and T cells

(Submitter supplied) Single-cell RNA sequencing (scRNAseq) allows the identification, characterization, and quantification of cell types in a tissue. When focused on B and T cells of the adaptive immune system, scRNAseq carries the potential to track the clonal lineage of each analyzed cell through the unique rearranged sequence of its antigen receptor (BCR or TCR, respectively), and link it to the functional state inferred from transcriptome analysis. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21697
3 Samples

Download data: CSV, DOCX, XLSX

Series

Accession:: GSE137275

ID:: 200137275

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Select item 20015764910.

Follicular T Cells are Clonally and Transcriptionally Distinct in B Cell-Driven Autoimmune Disease

(Submitter supplied) To better understand the role of follicular T cells in autoantibody-mediated disease, we performed single cell RNA and T cell receptor (TCR) sequencing of follicular T cells in a mouse model of autoantibody-mediated disease. This repository provides paired transcriptomes and unbiased TCRab repertoires from sorted CD4+CXCR5+PD1+ follicular T cells at single cell resolution. Our analysis revealed that a minority of clonotypes are preferentially shared amongst autoimmune follicular T cells, and clonotypic expansion is associated with differential gene signatures in autoimmune disease. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL19057
20 Samples

Download data: CSV

Series

Accession:: GSE157649

ID:: 200157649

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Select item 20024223411.

Microenvironmental network of clonal CXCL13+CD4+ T cells and regulatory T cells in pemphigus chronic blisters

(Submitter supplied) Pemphigus, a rare autoimmune bullous disease mediated by anti-desmoglein autoantibodies, can be controlled with systemic medication like rituximab and high-dose systemic corticosteroids combined with immunosuppressants. However, some patients continue to experience chronically recurrent blisters in a specific area, requiring long-term maintenance systemic therapy. We demonstrate the presence of skin tertiary lymphoid structures (TLSs) with desmoglein-specific B cells in chronic blisters from pemphigus patients. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL20301
8 Samples

Download data: CSV, MTX, TSV

Series

Accession:: GSE242234

ID:: 200242234

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Select item 20018287012.

Germline-like TCR alpha chains dominate shared self-reactive T cell receptors in type 1 diabetes

(Submitter supplied) Human islet antigen reactive CD4+ memory T cells (IAR T cells) play a key role in the pathogenesis of autoimmune type 1 diabetes (T1D). Using single cell RNA-sequencing (scRNA-seq) to identify T cell receptors (TCRs) in IAR T cells, we have identified a class of TCRs that share TCR alpha chains between individuals (“public”).

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL18573
3343 Samples

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Series

Accession:: GSE182870

ID:: 200182870

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Select item 20023180813.

Loss of B cell Tolerance is TCR Dependent

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Other; Protein profiling by protein array

Platform:: GPL33382
273 Samples

Download data: TXT

Series

Accession:: GSE231808

ID:: 200231808

Select item 20023180714.

Loss of B cell Tolerance is TCR Dependent [IgG2c CTD array]

(Submitter supplied) We used protein arrays to measure IgG2c autoantibodies associated with Connective Tissue Diseases (CTDs) from retrogenic chimeras Sera was isolated from irradiated Icos-/-;CD45.1 mice reconstituted with 564Igi;Icos-/- bone marrow mixed with Icos-/-;CD45.1 bone marrow and WT bone marrow (BMchim.564) or retrogenic HSCs expressing TCR-A (BMchim.564-Icos.RAG-TCRA), TCR-B (BMchim.564-Icos.RAG-TCRB), or TCR-C (BMchim.564-Icos.RAG-TCRC). more...

Organism:: Mus musculus

Type:: Protein profiling by protein array

Platform:: GPL33382
91 Samples

Download data: TXT

Series

Accession:: GSE231807

ID:: 200231807

Select item 20023180115.

Loss of B cell Tolerance is TCR Dependent [IgG2a CTD array]

(Submitter supplied) We used protein arrays to measure IgG2a autoantibodies associated with Connective Tissue Diseases (CTDs) from retrogenic chimeras Sera was isolated from irradiated Icos-/-;CD45.1 mice reconstituted with 564Igi;Icos-/- bone marrow mixed with Icos-/-;CD45.1 bone marrow and WT bone marrow (BMchim.564) or retrogenic HSCs expressing TCR-A (BMchim.564-Icos.RAG-TCRA), TCR-B (BMchim.564-Icos.RAG-TCRB), or TCR-C (BMchim.564-Icos.RAG-TCRC). more...

Organism:: Mus musculus

Type:: Protein profiling by protein array

Platform:: GPL33382
91 Samples

Download data: TXT

Series

Accession:: GSE231801

ID:: 200231801

Select item 20023179816.

Loss of B cell Tolerance is TCR Dependent [IgG CTD array]

(Submitter supplied) We used protein arrays to measure IgG autoantibodies associated with Connective Tissue Diseases (CTDs) from retrogenic chimeras Sera was isolated from irradiated Icos-/-;CD45.1 mice reconstituted with 564Igi;Icos-/- bone marrow mixed with Icos-/-;CD45.1 bone marrow and WT bone marrow (BMchim.564) or retrogenic HSCs expressing TCR-A (BMchim.564-Icos.RAG-TCRA), TCR-B (BMchim.564-Icos.RAG-TCRB), or TCR-C (BMchim.564-Icos.RAG-TCRC). more...

Organism:: Mus musculus

Type:: Protein profiling by protein array

Platform:: GPL33382
91 Samples

Download data: TXT

Series

Accession:: GSE231798

ID:: 200231798

Select item 20022992117.

Loss of B cell Tolerance is TCR Dependent [amplicon-seq]

(Submitter supplied) We tested orphan TCR autoreactivity using the peptide MHC-TCR chimeric receptor (MCR) co-culture system. In this system, cognate antigen recognition leads to TCR specific NFAT activation in MCR reporter cells expressing a mouse I-Ab MHC class II extracellular domain covalently linked to candidate peptides and an intracellular TCR signaling domain. We used mixed autoimmune bone marrow chimera spleens and kidneys as sources of cDNA to generate a transcriptome-wide library of natural autoantigen peptides . more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL19057
34 Samples

Download data: CSV

Series

Accession:: GSE229921

ID:: 200229921

PubMed Similar studies

Select item 20015977418.

PD-1 induced proliferating T cells exhibit a distinct transcriptional signature

(Submitter supplied) Analysis of primary human CD4+ T cells stained with the proliferation tracker CFSE and stimulated with anti-CD3, anti-CD28, and PDL1 or PDL2 for 5 days. Cells were sorted at the end of stimulation based on number of proliferative doublings prior to RNA isolation. Results provide insight into the PD-1 response pathway in CD4+ T cells that are proliferating or non-proliferating following stimulation.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21290
12 Samples

Download data: CSV

Series

Accession:: GSE159774

ID:: 200159774

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Select item 20024004119.

Using combined single-cell gene expression, TCR sequencing and cell surface protein barcoding to characterize and track CD4 T cell clones from murine tissues

(Submitter supplied) Single-cell gene expression analysis using sequencing (scRNA-seq) has gained increased attention in the past decades for studying cellular transcriptional programs and their heterogeneity in an unbiased manner, and novel protocols allow the simultaneous measurement of gene expression, T-cell receptor clonality and cell surface protein expression. In this article, we describe the methods to isolate scRNA/TCR-seq-compatible CD4+ T cells from murine tissues, such as skin, spleen, and lymph nodes. more...