Similar studies for GEO DataSets (Select 200184150) - GEO DataSets

Select item 2001841501.

Genome-Wide Association Study of Hospitalized COVID-19 Patients in the United Arab Emirates

(Submitter supplied) The heterogeneity in symptomatology and phenotypic profile attributable to COVID-19 is widely unknown. For the first time, our study provides the unique advantage of obtaining samples from the Middle Eastern population, an underrepresented region in genetic studies, and explore new genotypes in this population that will yield to novel genetic association. Specifically, we studied 646 patients in the United Arab Emirates. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by SNP array; SNP genotyping by SNP array

Platform:: GPL23391
646 Samples

Download data: CSV, IDAT, TXT

Series

Accession:: GSE184150

ID:: 200184150

PubMed Full text in PMC Similar studies

Select item 2002260842.

Microvascular and Macrovascuar Complications of Type 2 Diabetes Mellitus: Exome Wide Association Analyses

(Submitter supplied) With an escalating global burden, T2DM is associated to long-term complications that have contributed to the burden of morbidity and mortality worldwide. The objective of this manuscript is to conduct an Exome-Wide Association Study (EWAS) on T2DM Emirati individuals to improve our understanding on diabetes-related complications for a more enhanced disease management and improve therapeutic targets.

Organism:: Homo sapiens

Type:: SNP genotyping by SNP array

Platform:: GPL26511
310 Samples

Download data: IDAT, TXT

Series

Accession:: GSE226084

ID:: 200226084

PubMed Full text in PMC Similar studies

Select item 2001723683.

Multi-omics co-localization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Methylation profiling by array

Platforms:: GPL16791 GPL21145
396 Samples

Download data: IDAT

Series

Accession:: GSE172368

ID:: 200172368

PubMed Full text in PMC Similar studies

Select item 2001723674.

Multi-omics co-localization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus [RNA-Seq]

(Submitter supplied) We generated genome-wide gene expression data (RNAseq) from cultured airway epithelial cells exposed to rhinovirus (RV) and a vehicle control (48 hour treatment). This data was generated in combination with genome-wide DNA methylation data (RNAseq) and genotypes from the same individuals.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
190 Samples

Download data: TXT

Series

Accession:: GSE172367

ID:: 200172367

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001723655.

Multi-omics co-localization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus [Methylation array]

(Submitter supplied) We generated genome-wide DNA methylation data from cultured airway epithelial cells exposed to rhinovirus (RV) and a vehicle control (48 hour treatment). This data was generated in combination with genome-wide expression data (RNAseq) and genotypes from the same individuals.

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL21145
206 Samples

Download data: IDAT, TXT

Series

Accession:: GSE172365

ID:: 200172365

PubMed Full text in PMC Similar studies

Select item 2001617316.

Dysregulated transcriptional responses to SARS-CoV-2 in the periphery support novel diagnostic approaches

(Submitter supplied) In order to elucidate novel aspects of the host response to SARS-CoV-2 we performed RNA sequencing on 77 peripheral blood samples across 46 subjects with COVID-19 and compared them to subjects with seasonal coronavirus, influenza, bacterial pneumonia, and healthy controls. The transcriptome in peripheral blood reveals unique aspects of the immune response in COVID-19 and provides for novel biomarker-based approaches to diagnosis.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
198 Samples

Download data: CSV, TXT

Series

Accession:: GSE161731

ID:: 200161731

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001233527.

Transcriptome of non-involved lung parenchyma from ever and never smoker lung adenocarcinoma patients from Milan, Italy.

(Submitter supplied) Alteration of gene expression profile of target organs may signal exposure of that organ to toxic chemicals. We analyzed the transcriptome of the non-involved lung tissue, excised from 176 surgically treated lung adenocarcinoma patients, to identify genes whose expression levels were altered by individual habit to cigarette smoking. Of 17.097 genes analyzed, 357 resulted to be differentially expressed between never smokers and ever smokers (FDR <0.05). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
176 Samples

Download data: TXT

Series

Accession:: GSE123352

ID:: 200123352

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000711818.

Transcriptome of non-involved lung parenchyma from smoker lung adenocarcinoma patients from Milan, Italy.

(Submitter supplied) Scientific evidence indicates that genetic factors may contribute to differences in lung cancer risk for individuals with similar levels of tobacco exposure, which is the main environmental risk factor of lung cancer. Moreover, lung cancer patients show large differences in clinical staging and survival; these differences seem to be attributable, at least partially, to the genetic background. The analysis of the molecular properties (e.g., germline variations and genome-wide expression levels) of non-involved tissue from lung cancer patients may contribute in the identification of genetic factors involved in the development and progression of this pathology. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
284 Samples

Download data: TXT

Series

Accession:: GSE71181

ID:: 200071181

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002408889.

Circulating miRNA Profiles in COVID-19 Patients and Meta-Analysis: Implications for Disease Progression and Prognosis

(Submitter supplied) We compared circulating miRNA profiles of hospitalized COVID-positive patients (n = 104, 27 with ARDS) and age and gender matched healthy controls (n = 18) to identify miRNA signatures associated with COVID and COVID-induced ARDS. Meta-analysis incorporating data from published studies and our data was performed to identify a set of differentially expressed miRNAs in 1) COVID-positive patients versus healthy controls as well as 2) severe (ARDS+) COVID vs moderate COVID. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL21697
122 Samples

Download data: XLSX

Series

Accession:: GSE240888

ID:: 200240888

PubMed Full text in PMC Similar studies

Select item 20017579110.

Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus

(Submitter supplied) To identify a causative variant and effector gene responsible for a 2-fold increased risk of severe COVID-19, a multi-omics platform was deployed. A combination of ATAC-seq, ChIP-seq, Micro Capture-C and NuTi Capture-C were used to characterize a range of cell types, including epithelial, fibroblast, endothelial, immune and erythroid cells.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Other

Platform:: GPL18573
34 Samples

Download data: BW

Series

Accession:: GSE175791

ID:: 200175791

PubMed Full text in PMC Similar studies

Select item 20017579011.

Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus (MCC)

(Submitter supplied) To identify regulatory interactions in erythroid, fibroblast and endothelial cells Micro Caputre-C was carried outfrom the promoters of active genes as well as the rs17713054 containing enhancer.

Organism:: Homo sapiens

Type:: Other

Platform:: GPL18573
14 Samples

Download data: BW, TXT

Series

Accession:: GSE175790

ID:: 200175790

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20017578912.

Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus (ATAC-seq)

(Submitter supplied) To identify regions of open chromatin ATAC-seq was carried out in Blood outgrowth endothelial cells (BOECs) and NCI-H441 Epithelial cells

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
8 Samples

Download data: BW

Series

Accession:: GSE175789

ID:: 200175789

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20017578813.

Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus (ChIP-seq)

(Submitter supplied) To identify regulation by the CEBPB transcription factor in epithelial, fibroblast and endothelial cells ChIP-seq was carried out for both the transcription factor and marks of active transcription (H3K27ac).