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Links from GEO DataSets

Items: 6

1.

Association of tumor burden with the efficacy of PD-(L)1 inhibitors for treatment-naive advanced non-small-cell lung cancer

(Submitter supplied) A high tumor mutation was associated with a poor outcome of immune checkpoint inhibitor therapy for advanced NSCLC as a result of immunosuppressive phenotypes.
Organism:
Homo sapiens
Type:
Other
Platform:
GPL27956
51 Samples
Download data: RCC
Series
Accession:
GSE250262
ID:
200250262
2.

High baseline tumor burden-associated macrophages promote an immunosuppressive microenvironment and reduce the efficacy of immune checkpoint inhibitors through the IGFBP2-STAT3-PD-L1 pathway

(Submitter supplied) In order to study the difference between high tumor burden and low tumor burden, we established MC38 tumor-bearing mice. We then performed gene expression profiling analysis using data obtained from RNA-seq of 4 different cells at two time points.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
10 Samples
Download data: TXT
Series
Accession:
GSE227270
ID:
200227270
3.

The expression profiles of exosomal miRNAs associated with response to anti-PD-1/PD-L1 monotherapy in advanced NSCLC patients.

(Submitter supplied) Exosomal miRNAs involved in response to anti-PD-1/PD-L1 monotherapy in advanced NSCLC patients were successfully identified through the microoarray analysis.
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL21263
23 Samples
Download data: TXT
Series
Accession:
GSE189045
ID:
200189045
4.

T-cell CX3CR1 expression as a dynamic blood-based biomarker of response to immune checkpoint inhibitors

(Submitter supplied) We investigated the frequency of CX3CR1+CD8+ T cells in peripheral blood (PB) before and during immune checkpoint inhibitor (ICI) therapy, and delineated the TCR repertoire in peripheral CX3CR1+CD8+ T-cell subsets and CD8+ tumor-infiltrating lymphocytes (TILs) using preclinical models. To understand the clinical utility of CX3CR1 as a circulating T-cell biomarker, we analyzed longitudinal PB samples from non-small cell lung cancer (NSCLC) patients undergoing anti-PD-1 therapy, and evaluated predictive and prognostic value of changes in the frequency of PB CX3CR1+ CD8+ T cells Methods: Female C57BL/6 mice were inoculated subcutaneously with 5 x 10^5 MC38 tumor cells per mouse on the right flank on day 0. more...
Organism:
Mus musculus
Type:
Other
Platform:
GPL19057
12 Samples
Download data: TSV
Series
Accession:
GSE165383
ID:
200165383
5.

Multi-omic and spatial dissection of immunotherapy response groups in non-small cell lung cancer (NSCLC)

(Submitter supplied) DSP RNA profiling was performed on a cohort of immunotherapy treated NSCLC patients
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Other
Platform:
GPL18573
93 Samples
Download data: CSV, DCC, XLSX
Series
Accession:
GSE221733
ID:
200221733
6.

Multi-omic and spatial dissection of immunotherapy response groups in NSCLC

(Submitter supplied) Nanostring protein DSP was performed on 42 TMA cores of immunotherapy treated NSCLC patients
Organism:
Homo sapiens
Type:
Other
Platform:
GPL29263
96 Samples
Download data: CSV
Series
Accession:
GSE221322
ID:
200221322
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Supplemental Content

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