GEO DataSets

(Submitter supplied) Regulatory T lymphocytes expressing the transcription factor Foxp3 (Treg) play an important role in the prevention of autoimmune diseases and other immunopathologies. Aberrations in Treg-mediated immunosuppression are therefore thought to be involved in the development of autoimmune pathologies but few have been documented. Recent reports indicated a central role for Treg developing during the neonatal period in the prevention of autoimmune pathology. more...

Organism:

Mus musculus

Type:

Genome variation profiling by array

Platform:

GPL34100

96 Samples

Download data: IDAT

(Submitter supplied) Regulatory T lymphocytes (Treg) play a vital role in the protection of the organism against autoimmune pathology. It is therefore paradoxical that comparatively large numbers of Treg were found in the thymus of type I diabetes‐prone NOD mice. The Treg population in the thymus is composed of newly developing cells and cells that had recirculated from the periphery back to the thymus. We here demonstrate that exceptionally large numbers of Treg develop in the thymus of young, but not adult, NOD mice. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21493

6 Samples

Download data: TXT

(Submitter supplied) Regulatory T lymphocytes expressing the forkhead/winged helix transcription factor Foxp3 (Treg) play a vital role in the protection of the organism from autoimmune disease and other immunopathologies. The antigen-specificity of Treg plays an important role in their in vivo activity. We therefore assessed the diversity of the T cell receptors for antigen (TCR) expressed by Treg newly developed in the thymus of autoimmune type I diabetes-prone NOD mice and compared it to the control mouse strain C57BL/6. more...

Organism:

Mus musculus

Type:

Other

Platform:

GPL16417

24 Samples

Download data: TXT

(Submitter supplied) We used high density oligonucleotide arrays to measure the relative expression levels of >39,000 genes and ESTs in the NOD mouse (a murine model of T1D and other autoimmune conditions), four NOD-derived diabetes resistant congenic strains and two nondiabetic control strains. Owing to the importance of T cells in the development of T1D we decided to target two organs, the spleen and thymus. We profiled gene expression in thymi from four week old female mice and spleens from three month old female mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS10

Platform:

GPL24

28 Samples

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(Submitter supplied) Custom Affymetrix GeneChip designed by Eos Biotechnology Inc. to measure the expression of a large number of genes or ESTs on a single array. This is achieved by choosing those probes from within each set of 20 Affymetrix perfect match probes that show the least random fluctuation relative to the perceived specific hybridization over a wide ranging set of samples (Glynne et al. 2000). Experiments undertaken by Eos have revealed that the mismatch probes do not increase sensitivity or reproducibility (RJG and GG unpublished data). more...

Organism:

Mus musculus

1 DataSet

3 Series

28 Samples

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Examination of spleen and thymus of type 1 diabetes nonobese diabetic (NOD) mouse, four NOD-derived diabetes-resistant congenic strains and two nondiabetic control strains.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 disease state, 7 strain, 2 tissue sets

Platform:

GPL24

Series:

GSE11

28 Samples

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(Submitter supplied) miRNA expression profiling in highly purified murine CD4+ Tconv and Treg cells. FoxP3-GFP-hCre1a(high) reporter mice were used to separate both populations based on surface markers and presence or absence of GFP.

Organism:

Mus musculus

Type:

Non-coding RNA profiling by array

Platform:

GPL13960

1 Sample

Download data: GPR