Similar studies for GEO DataSets (Select 200255344) - GEO DataSets

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Items: 16

Select item 2002553441.

KMT9 is an actionable target in muscle-invasive bladder cancer

(Submitter supplied) Novel treatment modalities are imperative for the challenging management of muscle-invasive and metastatic BC to improve patient survival rates. The recently identified lysine methyltransferase (KMT) 9, an obligate heterodimer composed of KMT9α and KMT9β, regulates the growth of various types of tumors such as prostate, lung and colon cancer. While overexpression of KMT9α was previously observed to be associated with aggressive basal-like MIBC in an analysis of patients’ tissue samples, a potential functional role of KMT9 in this type of cancer has not been investigated to date. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
12 Samples

Download data: TXT

Series

Accession:: GSE255344

ID:: 200255344

PubMed Full text in PMC Similar studies

Select item 2001505062.

KMT9 controls growth and stemness of colorectal cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL24247 GPL13112 GPL11154
72 Samples

Download data: BED, WIG

Series

Accession:: GSE150506

ID:: 200150506

PubMed Similar studies

Select item 2001505053.

KMT9 controls growth and stemness of colorectal cancer [single-cell RNA-seq]

(Submitter supplied) The aim of the study is to identify cell-specific KMT9a target genes in AOMDSS tumour organoids

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
16 Samples

Download data: MTX, TSV

Series

Accession:: GSE150505

ID:: 200150505

PubMed Similar studies SRA Run Selector

Select item 2001505034.

KMT9 controls growth and stemness of colorectal cancer [RNA-Seq]

(Submitter supplied) The aim of the study is to identify KMT9α target genes in AOM/DSS tumour organoids, APK and APKK organoids, patient derived CRC organoids, AOM/DSS mouse tumours and normal mouse colon

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL13112 GPL11154
52 Samples

Download data: TXT

Series

Accession:: GSE150503

ID:: 200150503

PubMed Similar studies SRA Run Selector

Select item 2001505025.

KMT9 controls growth and stemness of colorectal cancer [ChIP-seq]

(Submitter supplied) The aim of the study is to identify KMT9a target genes in AOMDSS tumour organoids

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
4 Samples

Download data: BED, WIG

Series

Accession:: GSE150502

ID:: 200150502

PubMed Similar studies SRA Run Selector

Select item 2002355956.

Structure-guided design of a selective inhibitor of the methyltransferase KMT9 with cellular activity

(Submitter supplied) Inhibition of epigenetic regulators by small molecules is an attractive strategy for cancer treatment. Recently, we characterised the role of lysine methyltransferase 9 (KMT9) in prostate, lung, and colon cancer. Our observation that the enzymatic activity was required for tumour cell proliferation identified KMT9 an attractive therapeutic target. Here, we report the development of the first-in-class, potent and selective KMT9 inhibitor (compound 4, KMI169) through structure-based drug design. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
9 Samples

Download data: TXT

Series

Accession:: GSE235595

ID:: 200235595

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001258827.

KMT9 writes the H4K12me1 histone mark and controls metabolism and proliferation of castration-resistant prostate cancer cells [ChIP-Seq 2]

(Submitter supplied) The aim of the study is to identify KMT9a target genes in PC-3M cells

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
6 Samples

Download data: WIG

Series

Accession:: GSE125882

ID:: 200125882

PubMed Similar studies SRA Run Selector

Select item 2001175368.

KMT9a writes the H4K12me1 histone mark and controls metabolism and proliferation of castration-resistant prostate cancer cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below. Posttranslational modifications of histones such as methylation regulate chromatin structure and gene expression. Methylation of histone lysine residues is generally performed by SET domain methyltransferases. Here, we identify the heterodimeric C21orf127/TRMT112 complex as a histone methyltransferase. Assembly of the seven-b-strand protein C21orf127 (also named Hemk2, N6amt1 or PrmC) with TRMT112 is essential to form an active enzyme, hereafter named KMT9 that writes the histone mark H4K12me1 in vitro and in vivo. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:: GPL11154
34 Samples

Download data: BED, WIG

Series

Accession:: GSE117536

ID:: 200117536

PubMed Similar studies

Select item 2001175359.

KMT9a writes the H4K12me1 histone mark and controls metabolism and proliferation of castration-resistant prostate cancer cells [RNA-seq]

(Submitter supplied) The aim of the RNA-seq was to identify the KMT9 transcriptome in PC-3M cells. The MCF10A breast epithelial cells that do not express KMT9a were used to show that the siRNA against KMT9 show no off-target effects.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
12 Samples

Download data: XLSX

Series

Accession:: GSE117535

ID:: 200117535

Select item 20011753410.

KMT9 writes the H4K12me1 histone mark and controls metabolism and proliferation of castration-resistant prostate cancer cells [ChIP-seq]

(Submitter supplied) KMT9 is formed by the assembly of KMT9a and KMT9b and writes the H4K12me1 mark. The objectives of this study is to identify KMT9a, KMT9b, and H4K12me1 locations by ChIP-seq in the androgen-independent PC-3M prostate cancer cells and to show that upon KMT9a knockdown the levels of H4K12me1 mark decrease.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
16 Samples

Download data: BED, WIG

Series

Accession:: GSE117534

ID:: 200117534

PubMed Similar studies SRA Run Selector

Select item 20014770911.

Trp53 mutation in Krt5-expressing basal cells facilitates the development of basal squamous-like invasive bladder cancer in the chemical carcinogenesis of mouse bladder

(Submitter supplied) We investigated the genetic characteristics of the mouse tumors. First, we investigated whether mouse BBN-induced bladder cancers displayed distinct gene expression profiles according to the cell of origin or pre-induced Trp53 mutation. Gene expression profiles based on cDNA microarray data were analyzed using non-hierarchical clustering, which revealed that none of the mouse bladder tumors were differentially clustered based on the genotypes.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL21163
22 Samples

Download data: GCT, TXT

Series

Accession:: GSE147709

ID:: 200147709

Select item 20018196212.

PDX bank from urothelial cancer to guide precision medicine.

(Submitter supplied) We developed preclinical PDX models, recapitulating the molecular heterogeneity of MIBCs and UTUC, which will represent an essential tool in therapy development. Pharmacological characterization of the PDXs suggested that upper urinary tract and bladder cancers (UCC/ SCC) with similar molecular characteristics could benefit from the same treatments, and showed a benefit for combined FGFR/EGFR inhibition in FGFR3-mutant PDXs, compared to FGFR inhibition alone.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL28327
54 Samples

Download data: CEL

Series

Accession:: GSE181962

ID:: 200181962

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20017944013.

Integrative Transcriptomic, Lipidomic, and Metabolomic Analysis Reveals Potential Biomarkers of Basal and Luminal Muscle Invasive Bladder Cancer Subtypes

(Submitter supplied) Muscle invasive bladder cancer (MIBC) is a heterogeneous disease with a high recurrence rate and poor clinical outcomes. Molecular subtype provides a new framework for the study of MIBC heterogeneity. Clinically, MIBC can be classified as basal and luminal subtypes, they display different clinical and pathological characteristics, but the molecular mechanism is still unclear. Lipidomic and metabolomic molecules have recently been considered to play an important role in the genesis and development of tumors, especially as potential biomarkers. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
12 Samples

Download data: XLSX

Series

Accession:: GSE179440

ID:: 200179440

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20015188814.

Gene expression data from FGFR3 induced mouse bladder tumors

(Submitter supplied) Somatic mutations of the fibroblast growth factor receptor 3 (FGFR3) are one of the most frequent genetic alterations in bladder carcinomas. We report here that human-FGFR3-S249C expression in urothelial cells of transgenic mice induces low-grade papillary tumors presenting genomic instability and resembling human pTa urothelial tumors at the transcriptomic level. Mutated-FGFR3 expression levels impacted the incidence of tumor formation and could account for the tissue specificity of human mutated FGFR3-driven tumors restricted to epithelia presenting high normal expression levels of FGFR3.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL28635
15 Samples

Download data: CEL

Series

Accession:: GSE151888

ID:: 200151888

Select item 20007795215.

Comparison of gene expression profiling of human non-muscle invasive bladder cancer and muscle invasive bladder cancer

(Submitter supplied) The biological behaviors, clinical treatment, prognosis of nonmuscle-invasive bladder cancers (NMIBCs) and muscle-invasive bladder cancers (MIBCs) are distinct. Therefore, we performed high-through microarray screening of mRNA expression in 30 bladder tumors, to filter out some of the differential expression genes in NMIBCs and MIBCs.A total of 11 Genes in MIBCs versus in NMIBCs were considered differentially transcribed if they were transcribed ≤2.0 fold change and p<0.001 by unpaired T-test, including 9 up-regulated genes and 2 down-regulated genes in MIBCs (NR4A2, PLK3, CYR61, APOLD1, C13ORF33, LIG4, RBMS3, PCK2, AK098422, HSD17B3, RTN4). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6480
30 Samples

Download data: TXT

Series

Accession:: GSE77952

ID:: 200077952

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20021353316.

FLI1 and FRA1 transcription factors drive the transcriptional regulatory networks characterizing muscle invasive bladder cancer

(Submitter supplied) Bladder cancer is mostly present in the form of urothelium carcinoma, causing over 150.000 deaths each year. Its histopathological classification as muscle invasive and non-muscle invasive is the most prominent aspect, affecting the prognosis and progression of this disease. In this study, we defined the active regulatory landscape of MIBC and NMIBC cell lines using H3K27ac-seq and used an integrative data approach to combine our findings with existing data. more...