GEO DataSets

(Submitter supplied) 63 samples were profiled in replicates on Affymetrix microarrays and using a custom RNASeq panel. The samples were randomly split in a training and validation cohort. SET ER/PR was calculated and a linear model was trained and validated to reproduce values obtained by microarray using RNASeq. In addition, the microarray replicates were used to validate the technical reproducibility of SET ER/PR.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

128 Samples

Download data: CEL

(Submitter supplied) To evaluate the effect of tissue type (cytology vs. surgical tissue) on gene expression measurements. Information was used to select probesets with a high spatial reproducibility for the development of gene signatures.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

232 Samples

Download data: CEL

(Submitter supplied) To evaluate the effect of technical repetition on gene expression measurements, we repeated the laboratory protocol at 6 different steps. Information was used to select probesets with a high technical reproducibility for the development of gene signatures.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

120 Samples

Download data: CEL

(Submitter supplied) To evaluate the effect of intratumorally heterogeneity on gene expression measurements, we profiled and compared samples from different macroscopic tumor areas. Information was used to select probe sets with a high spatial reproducibility for the development of gene signatures.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

153 Samples

Download data: CEL

(Submitter supplied) 88 breast cancer samples were profiled on Affymetrix U133A and Plus2 microarrays.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL96 GPL570

176 Samples

Download data: CEL

(Submitter supplied) Samples from hormone-receptor positive breast cancer to identify transcripts related to ESR1 and PGR expression.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

147 Samples

Download data: CEL

(Submitter supplied) There is clinical need to predict sensitivity of metastatic hormone receptor-positive and HER2-negative (HR+/HER2-) breast cancer to endocrine therapy, and targeted RNA sequencing (RNAseq) offers diagnostic potential to measure both transcriptional activity and functional mutation. We developed the SETER/PR index to measure gene expression microarray probe sets that were correlated with hormone receptors (ESR1 and PGR) and robust to pre-analytical and analytical influences. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL96 GPL570

1196 Samples

Download data: CEL

(Submitter supplied) There is clinical need to predict sensitivity of metastatic hormone receptor-positive and HER2-negative (HR+/HER2-) breast cancer to endocrine therapy, and targeted RNA sequencing (RNAseq) offers diagnostic potential to measure both transcriptional activity and functional mutation. We developed the SET ER/PR index to measure gene expression microarray probe sets that were correlated with hormone receptors (ESR1 and PGR) and robust to pre-analytical and analytical influences. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

140 Samples

Download data: CEL

(Submitter supplied) PURPOSE: To estimate the effect of contamination with normal breast tissue for the development of gene signatures robust to pre-analytical conditions. METHODS: We evaluated the effect of contamination with normal breast tissue on gene signatures by comparing microarray profiles of breast cancer samples contaminated with increasing amounts of normal breast tissue.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

100 Samples

Download data: CEL