Histone lactylation antagonizes senescence via facilitating gene-expression reprogramming.

Small-molecule inhibition of PRMT5 activates p53 in erythropoiesis through perturbation of mRNA processing, transport and protein translation

CRIPSR screen identified CLEC16A suppresses astrocyte inflammasome-involved pathology via mitophagy

Single-cell multi-omics in human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation.

Multi-omic analysis of cell-of-origin and epigenomic state in pediatric H3K27M gliomas

Reversal of RNA toxicity in myotonic dystrophy via a decoy RNA-binding protein with high affinity for expanded CUG repeats

Simple oligonucleotide-based multiplexing of single-cell chromatin accessibility

Telomerase Reverse Transcriptase Preserves Neuron Survival and Cognition in Alzheimer's Disease Models

Rett Syndrome linked to defects in forming the MeCP2/Rbfox/LASR complex in mouse models

Activation of AhR by ITE in DCs induces differential gene expression over time.

Unique features of co-existence of classical neutrophils and polymorphonuclear myeloid-derived suppressor cells in cancer

The Msi1-mTOR pathway drives the pathogenesis of Paget's disease

Pharmacological LSD1 inhibition in MCC

DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumour immunotolerance

Altered mRNA splicing by mutant p53 activates oncogenic RAS in pancreatic cancer

XPO5 is required for miRNA biogenesis and promotes primary miRNA processing independent of RanGTP

Transcriptional regulation of tDNA in H9 ESCs

Subclonal cooperation drives metastasis through modulating local and systemic immune microenvironments

Endothelial-AGO1-knockout (EC-AGO1-KO) mice and wild-type (WT) littermates

Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion