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| Status |
Public on Jun 23, 2017 |
| Title |
PGC-1a Provides a Transcriptional Framework for Synchronous Neurotransmitter Release from ParvalbuminPositive Interneurons |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
PGC-1a is a master regulator for cell mitochondrial and metabolism function. In this experiment neurons were infected with a PGC-1a/GFP adenovirus to examine what genes were upregulated by over expression. Known targets related to mitochondrial health were confirmed while new neuron specific targets were discovered.
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| Overall design |
SHSY5Y cells were infected with an adenovirus containing either GFP or GFP and PGC-1a and then had their transcriptome hybridized to a microarray to observe what genes were affected.
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| Contributor(s) |
Lucas EK, Dougherty SE, McMeekin LJ, Reid CS, Dobrunz LE, West AB, Hablitz JJ, Cowell RM |
| Citation(s) |
25339750 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| R01 NS070009 |
PGC-1alpha and GABAergic Dysfunction in Huntington Disease |
UNIVERSITY OF ALABAMA AT BIRMINGHAM |
Rita Marie Cowell |
|
| Submission date |
Jun 22, 2017 |
| Last update date |
Apr 25, 2022 |
| Contact name |
Rita M Cowell |
| E-mail(s) |
rcowell@southernresearch.org
|
| Phone |
205-581-2216
|
| Organization name |
Southern Research
|
| Department |
Neuroscience
|
| Street address |
2000 9th Avenue South
|
| City |
Birmingham |
| State/province |
AL |
| ZIP/Postal code |
35205 |
| Country |
USA |
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| Platforms (1) |
| GPL6884 |
Illumina HumanWG-6 v3.0 expression beadchip |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA391482 |
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