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| Status |
Public on Jul 21, 2017 |
| Title |
Shared αβ T Cell Receptor Usage in Lungs of Sarcoidosis Patients with Löfgren’s Syndrome [iRepertoire] |
| Organism |
Homo sapiens |
| Experiment type |
Other
|
| Summary |
Expansions of CD4+ T cells utilizing TRAV12-1 and TRBV2 were found exclusively in HLA-DR3+ LS patients. These TCRs shared CDR3 homology, suggesting that these T cells are responsible for recognizing sarcoidosis-associated antigen(s) and are involved in the local alveolitis.
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| |
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| Overall design |
Analysis of TCR sequences from 13 sarcoidosis and 3 control patient blood and/or lung samples.
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| |
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| Contributor(s) |
Mitchell AM, Kaiser Y, Falta MT, Munson DJ, Eklund A, Slansky JE, Grunewald J, Fontenot AP |
| Citation(s) |
28827283 |
| Submission date |
Jun 22, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Andrew P Fontenot |
| E-mail(s) |
andrew.fontenot@ucdenver.edu
|
| Organization name |
University of Colorado Denver
|
| Department |
Dept. of Medicine
|
| Lab |
Andrew Fontenot
|
| Street address |
12700 E 19th Ave, P15, Rm 10410
|
| City |
Aurora |
| State/province |
Colorado |
| ZIP/Postal code |
80045 |
| Country |
USA |
| |
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| Platforms (1) |
|
| Samples (23)
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| This SubSeries is part of SuperSeries: |
| GSE100558 |
Shared αβ T Cell Receptor Usage in Lungs of Sarcoidosis Patients with Löfgren’s Syndrome |
|
| Relations |
| BioProject |
PRJNA391483 |
| SRA |
SRP110174 |
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