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| Status |
Public on Aug 18, 2017 |
| Title |
Effects of Inhibition of CDK8/19 Mediator Kinase by Senexin A in HEK293 cells treated with TNF-alpha I |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
We have investigated the effects of CDK8/19 inhibitor Senexin A on NFκB-mediated transcription, induced by a canonical NFκB activator, TNFα.
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| Overall design |
HEK293 cells were pre-treated with or without 5 μM Senexin A for 1 hour, followed by treatment with or without 10 ng/ml TNFα for 30 minutes.
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| Contributor(s) |
Chen M, Liang J, Ji H, Yang Z, Altilia S, Hu B, Schronce A, McDermott M, Schools GP, Lim C, Oliver D, Shtutman MS, Lu T, Stark GR, Porter DC, Broude EV, Roninson IB |
| Citation(s) |
28855340 |
| Submission date |
Jul 19, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Mengqian Chen |
| E-mail(s) |
chenm@cop.sc.edu
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| Organization name |
University of South Carolina
|
| Department |
College of Pharmacy
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| Street address |
CLS710, 715 Sumter Street
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| City |
Columbia |
| State/province |
SC |
| ZIP/Postal code |
29208 |
| Country |
USA |
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| Platforms (1) |
| GPL14550 |
Agilent-028004 SurePrint G3 Human GE 8x60K Microarray (Probe Name Version) |
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| Samples (16)
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| This SubSeries is part of SuperSeries: |
| GSE101630 |
Effects of Inhibition of CDK8/19 Mediator Kinase by Senexin B in HCT116 and HEK293 cells treated with or without TNF-alpha |
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| Relations |
| BioProject |
PRJNA395031 |
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