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| Status |
Public on Apr 01, 2019 |
| Title |
The role of TEFM in mitochondrial gene expression [smallRNA] |
| Organism |
Mus musculus |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
|
| Summary |
We investigated the role of TEFM in vivo by creating heart- and skeletal-muscle specific knockout of this gene. We identified that TEFM is required for the processivity of POLRMT and its loss leads to significantly decreased mitochondrial transcription.
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| Overall design |
Small RNA from isolated heart mitochondria from four control mice (L/L) and four Tefm knockout mice (L/L, cre), was sequenced and analysed for differential expression.
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| |
|
| Contributor(s) |
Siira S, Filipovska A |
| Citation(s) |
31036713 |
| Submission date |
Aug 04, 2017 |
| Last update date |
Jan 07, 2024 |
| Contact name |
Stefan J Siira |
| Organization name |
Harry Perkins Institute of Medical Research
|
| Department |
Molecular medicine
|
| Lab |
Mitochondrial medicine and biology
|
| Street address |
6 Verdun St, Nedlands
|
| City |
Perth |
| State/province |
Western Australia |
| ZIP/Postal code |
6009 |
| Country |
Australia |
| |
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| Platforms (1) |
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| Samples (7)
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| This SubSeries is part of SuperSeries: |
| GSE102255 |
The role of TEFM in mitochondrial gene expression |
|
| Relations |
| BioProject |
PRJNA397135 |
| SRA |
SRP114826 |
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