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Status |
Public on Apr 01, 2019 |
Title |
The role of TEFM in mitochondrial gene expression [TruSeq] |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
We investigated the role of TEFM in vivo by creating heart- and skeletal-muscle specific knockout of this gene. We identified that TEFM is required for the processivity of POLRMT and its loss leads to significantly decreased mitochondrial transcription.
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Overall design |
Total RNA from isolated heart mitochondria from four control mice (L/L) and four Tefm knockout mice (L/L, cre), was sequenced and analysed for differential expression.
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Contributor(s) |
Siira S, Filipovska A |
Citation(s) |
31036713 |
Submission date |
Aug 04, 2017 |
Last update date |
Jan 07, 2024 |
Contact name |
Stefan J Siira |
Organization name |
Harry Perkins Institute of Medical Research
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Department |
Molecular medicine
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Lab |
Mitochondrial medicine and biology
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Street address |
6 Verdun St, Nedlands
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City |
Perth |
State/province |
Western Australia |
ZIP/Postal code |
6009 |
Country |
Australia |
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Platforms (1) |
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Samples (8)
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This SubSeries is part of SuperSeries: |
GSE102255 |
The role of TEFM in mitochondrial gene expression |
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Relations |
BioProject |
PRJNA397137 |
SRA |
SRP114827 |