|
| Status |
Public on Feb 14, 2018 |
| Title |
Profiling of expression data in melanoma cells following DOT1L shRNA knockdown |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
DOT1L-dependent H3K79 methylation is associated with telomere silencing, meiotic checkpoint control, DNA repair, modulation of constitutive heterochromatin, and transcriptional activation.
|
| |
|
| Overall design |
We used microarrays to detail the global program of gene expression in C021 melanoma cells following treatment with shRNA against DOT1L or scrambled control.
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| |
|
| Contributor(s) |
Zhu B, Cui R |
| Citation(s) |
29343685 |
| Submission date |
Aug 24, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Boston University Microarray and Sequencing Resource |
| E-mail(s) |
msrdata@bu.edu
|
| Organization name |
Boston University
|
| Department |
Microarray and Sequencing Resource
|
| Street address |
72 East Concord Street, E631
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02118 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL17930 |
[HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [HuGene20stv1_Hs_ENTREZG_17.0.0] |
|
| Samples (6)
|
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| This SubSeries is part of SuperSeries: |
| GSE103081 |
Profiling of expression data in melanoma cells with mutant DOT1L, DOT1L inhibitor or shRNA knockdown |
|
| Relations |
| BioProject |
PRJNA400279 |
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