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| Status |
Public on Jul 19, 2018 |
| Title |
Transcriptome-wide gene expression analysis of the cancer cell lines after treatiment with telomerase inhibitor Imetelstat (GRN163L) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
GRN163L is a potent and specific telomerase inhibitor and in clinical trials for cancer treatment. To identify the biomarker that might predict response to telomease based therapy, gene expression analysis of the cancer cell lines after treatiment with telomerase inhibitor Imetelstat (GRN163L) was performed.
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| Overall design |
HCT116, Colo205, OVCAR5 cells were either vehicle treated or Imetelstat treated for 2 weeks and then total RNA was preppared, which was then used to analyze for gene expression using Illumina expression array.
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| Contributor(s) |
Gupta R, Wajapeyee N, Dogra S |
| Citation(s) |
29986697 |
| Submission date |
Nov 05, 2017 |
| Last update date |
Aug 13, 2018 |
| Contact name |
Narendra Wajapeyee |
| E-mail(s) |
nwajapey@uab.edu
|
| Phone |
205-934-5331
|
| Organization name |
University of Alabama at Birmingham
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| Department |
Department of Biochemistry and Molecular Genetics
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| Street address |
720 20th Street South, Kaul 540A
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| City |
Birmingham |
| State/province |
AL |
| ZIP/Postal code |
35233 |
| Country |
USA |
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| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA417570 |
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