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| Status |
Public on Nov 05, 2020 |
| Title |
Developmental Exposure to Endocrine-Disrupting Chemicals Alters Gene Expression in Myometrium of Exposed Animals |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The goal of this study was to compare NGS-derived murine myometrial progenitor cell transcriptome profiling (RNA-seq) of an animal model of uterine fibroid tumorigenesis in rats exposed during uterine development to an endocrine-disrupting chemical, diethylstilbestrol (DES) versus vehicle (VEH) control, unexposed animals, to determine the pathways and biological processes, whose gene expression may be altered as a result of the exposure.
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| Overall design |
Examination of gene expression in exposed vs. unexposed murine myometrial progenitor cells; myometrial progenitor cells isolated from 5 exposed animals were pooled and compared to that of the same cells isolated from 5 unexposed animals
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| Contributor(s) |
Al-Hendy A, Yang Q, Mas A, Prusinski Fernung LE |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Nov 08, 2017 |
| Last update date |
Nov 05, 2020 |
| Contact name |
Ayman Al-Hendy |
| E-mail(s) |
aalhendy@augusta.edu
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| Organization name |
Augusta University
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| Department |
Obstetrics and Gynecology
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| Street address |
1120 15th Street
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| City |
AUGUSTA |
| State/province |
Georgia |
| ZIP/Postal code |
30912 |
| Country |
USA |
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| Platforms (1) |
| GPL18694 |
Illumina HiSeq 2500 (Rattus norvegicus) |
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| Samples (2) |
| GSM2844581 |
VEH-exposed myometrial progenitor cells |
| GSM2844582 |
DES-exposed myometrial progenitor cells |
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| Relations |
| BioProject |
PRJNA417556 |
| SRA |
SRP124585 |
