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| Status |
Public on Oct 29, 2018 |
| Title |
Transcriptome analysis of Chrdl1-treated RGCs |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Chrdl1 treatment promotes formation of synapses and GluA2-AMPAR recruitment in Retinal ganglion cell (RGC) cultures. Analysis of the transcriptome of RGCs with or without Chrdl1 treatment let us determine potential alterations in the expression of genes related to BMP signaling, or genes involved in excitatory synaptogenesis and AMPAR trafficking.
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| |
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| Overall design |
RNA was isolated from RGC cultures treated for 12 hours with 1ug/ml Chrdl1, and compared to RNA isolated from buffer-treated (vehicle) RGCs as a control.
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| |
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| Contributor(s) |
Blanco-Suarez E, Shokhirev MN, Allen N |
| Citation(s) |
30344043 |
| Submission date |
Dec 23, 2017 |
| Last update date |
Mar 28, 2022 |
| Contact name |
April Elizabeth Williams |
| E-mail(s) |
apriljack06@gmail.com, awilliams@salk.edu
|
| Phone |
7345461645
|
| Organization name |
Salk Institute for Biological Studies
|
| Department |
IGC
|
| Street address |
10010 N Torrey Pines Rd
|
| City |
San Diego |
| State/province |
California |
| ZIP/Postal code |
92037 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL18694 |
Illumina HiSeq 2500 (Rattus norvegicus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA427397 |
| SRA |
SRP127490 |
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