|
| Status |
Public on Jan 05, 2018 |
| Title |
Targeting the vulnerability of RB tumor suppressor loss in triple negative breast cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Approximately 30% of TNBCs exhibit loss of function of the RB tumor suppressor. The study used RNA sequencing to profile RB-proficient and RB-deficient TNBC cases that were defined based on immunostaining for RB and p16ink4a. The analyses revealed that RB-deficient TNBC cases express elevated levels of DNA replication and mitotic genes that could serve as the basis for increased sensitivity to drugs targeting cell cycle checkpoints.
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| |
|
| Overall design |
The study compared normal tissue, RB-positive, and RB-deficient TNBC. RNA sequencing was utilized to define differentially expressed genes.
|
| |
|
| Contributor(s) |
Witkiewicz A, Knudsen ES |
| Citation(s) |
29386107 |
| Submission date |
Jan 04, 2018 |
| Last update date |
Feb 10, 2020 |
| Contact name |
Adam David Grant |
| E-mail(s) |
adglink@email.arizona.edu
|
| Phone |
801-471-6751
|
| Organization name |
University of Arizona
|
| Department |
Cancer Biology
|
| Lab |
Erik Knudsen
|
| Street address |
3760 E. Felix Blvd
|
| City |
Tucson |
| State/province |
Arizona |
| ZIP/Postal code |
85706 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL13393 |
AB SOLiD 4 System (Homo sapiens) |
|
| Samples (13)
|
|
| Relations |
| BioProject |
PRJNA428502 |
| SRA |
SRP130931 |
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