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| Status |
Public on Mar 11, 2018 |
| Title |
Gene expression profile of colorectal cancer cell Caco-2 after OCC-1 knockdown |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
OCC-1 is one of the earliest annotated long noncoding RNAs (lncRNAs) in colorectal cancer (CRC). In our study, we found that knockdown of OCC-1 by shRNAs promotes CRC cell growth both in vitro and in vivo.
To gain insight into the molecular function of OCC-1, we profiled the gene expression of Caco-2 cells after OCC-1 knockdown by microarray.
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| Overall design |
OCC-1 was knockdown by two independent shRNAs, shOCC-1-1 and -2, in Caco-2 cells. The change of gene expression was determined relative to a non-target shRNA control, shCTRL. Overlapped differentially expressed genes in shOCC-1-1 and -2 cells were considered as OCC-1 regulated genes.
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| Contributor(s) |
Lan Y, Song X |
| Citation(s) |
29931370 |
| Submission date |
Jan 05, 2018 |
| Last update date |
Aug 23, 2018 |
| Contact name |
Yang Lan |
| Organization name |
Sichuan University
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| Department |
Center for Functional Genomics and Bioinformatics
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| Street address |
No. 29 Wangjiang Road
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| City |
Chengdu |
| ZIP/Postal code |
610064 |
| Country |
China |
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| Platforms (1) |
| GPL15207 |
[PrimeView] Affymetrix Human Gene Expression Array |
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| Samples (3) |
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| Relations |
| BioProject |
PRJNA428731 |
