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| Status |
Public on Dec 26, 2018 |
| Title |
Expression profiling of CD8+ T-cells in peripheral blood (PB) of AML patients |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
1) Transcriptional profiles of highly purified (≥ 98%) PB CD8+ T-cells from newly diagnosed AML patients (pre-treatment) were compared to age-matched healthy controls and transcriptional profiles of PB AML CD8+ T-cells from patients who achieved complete remission (CR) versus non-responders (NR) longitudinally, at pre-treatment and upon recovery following induction chemotherapy (paired samples).
2) Transcriptional profiles of PB AML CD8+ T-cells from patients who achieved complete remission (CR) versus non-responders (NR) longitudinally, at pre-treatment (PRE) and upon recovery following induction chemotherapy (POST) (paired samples).
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| Overall design |
1) AML patients vs. Healthy controls 2) AML patients induction chemotherapy responders (CR) versus non-responders (NR) at pretreatment (PRE) and upon recovery following induction chemotherapy (POST).
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| Contributor(s) |
Knaus H, Luznik L |
| Citation(s) |
30385732 |
| Submission date |
Jan 15, 2018 |
| Last update date |
Dec 26, 2018 |
| Contact name |
Hanna A Knaus |
| Organization name |
Johns Hopkins
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| Department |
Oncology
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| Lab |
Luznik Lab
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| Street address |
1650 Orleans St
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| City |
Baltimore |
| State/province |
Maryland |
| ZIP/Postal code |
21231 |
| Country |
USA |
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| Platforms (1) |
| GPL15207 |
[PrimeView] Affymetrix Human Gene Expression Array |
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| Samples (19)
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| GSM2934953 |
AML patient #2, after therapy |
| GSM2934954 |
AML patient #3, before therapy |
| GSM2934955 |
AML patient #3, after therapy |
| GSM2934956 |
AML patient #4, before therapy |
| GSM2934957 |
AML patient #4, after therapy |
| GSM2934958 |
AML patient #5, before therapy |
| GSM2934959 |
AML patient #5, after therapy |
| GSM2934960 |
AML patient #6, before therapy |
| GSM2934961 |
AML patient #6, after therapy |
| GSM2934962 |
Healthy control #1 |
| GSM2934963 |
Healthy control #2 |
| GSM2934964 |
Healthy control #3 |
| GSM2934965 |
Healthy control #4 |
| GSM2934966 |
AML patient #7, before therapy |
| GSM2934967 |
AML patient #8, before therapy |
| GSM2934968 |
AML patient #9, before therapy |
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| Relations |
| BioProject |
PRJNA430027 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE109179_RAW.tar |
36.0 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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