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| Status |
Public on Mar 01, 2009 |
| Title |
Expression data from tibialis anterior muscle |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
We generated transgenic mice expressing constitutively SOCS-3 specifically in skeletal muscle. SOCS proteins are implicated in the negative regulation of various pathways including insulin signaling pathway. Our transgenic mice are predisposed to obesity and systemic insulin resistance compared to control mice.
We used microarrays to detail the variations of gene expression in muscle from transgenic mice versus controls.
Keywords: transgenic, tibialis anterior, SOCS-3
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| Overall design |
Tibialis anterior is a mixed muscle easy to extract. Our previous investigations showed that this muscle expressed high level of the SOCS-3 transgene.
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| Contributor(s) |
Cognard E, Lebrun P, Paul R, Filloux C, Van Obberghen E |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Apr 09, 2008 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Kevin Lebrigand |
| Organization name |
IPMC/CNRS
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| Lab |
Functional Genomics Platform of Nice-Sophia-Antipolis, France.
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| Street address |
660 route des lucioles
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| City |
Valbonne - Sophia-Antipolis |
| ZIP/Postal code |
06560 |
| Country |
France |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (6)
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| GSM280418 |
Tibialis anterior muscle from control C57Bl6J mice rep1 |
| GSM280419 |
Tibialis anterior muscle from control C57Bl6J mice rep2 |
| GSM280420 |
Tibialis anterior muscle from control C57Bl6J mice rep3 |
| GSM280421 |
Tibialis anterior muscle from MLC-SOCS-3/C57Bl6J mice rep1 |
| GSM280422 |
Tibialis anterior muscle from MLC-SOCS-3/C57Bl6J mice rep2 |
| GSM280423 |
Tibialis anterior muscle from MLC-SOCS-3/C57Bl6J mice rep3 |
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| Relations |
| BioProject |
PRJNA106991 |
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