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| Status |
Public on Mar 02, 2018 |
| Title |
Characterization of Transcriptomes of Apical OHCs and Basal OHCs in Cochlea |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We analyzed the transcriptomes of 30 isolated apical OHCs and basal OHCs from rat cochlea, and the results showed that more than 50 genes were differentially expressed and 20 genes were uniquely expressed among these populations. We analyzed these genes with a focus on their functions related to cellular structure and transmembrane channels and their vulnerability to and involvement in hereditary deafness caused by OHC defects. Our results could serve as a guideline for exploring the molecular mechanisms underlying the biological properties of OHCs.
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| |
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| Overall design |
2 sub-populations of cochlear outer hair cells with different gene expression related to thair differences in structure, function and vulnerability
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| |
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| Contributor(s) |
Qiu J, Qiu Y, Qi M |
| Citation missing |
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| Submission date |
Mar 01, 2018 |
| Last update date |
Jun 28, 2018 |
| Contact name |
Jianhua Qiu |
| E-mail(s) |
qiujh@fmmu.edu.cn
|
| Organization name |
Xijing Hospital, Fourth Military Medical University
|
| Department |
Otolaryngology Head & Neck Surgery
|
| Street address |
127 West Changle Rd
|
| City |
Xi'an |
| State/province |
Shaanxi |
| ZIP/Postal code |
710032 |
| Country |
China |
| |
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| Platforms (1) |
| GPL14844 |
Illumina HiSeq 2000 (Rattus norvegicus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA436547 |
| SRA |
SRP133752 |
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