|
| Status |
Public on Jun 20, 2018 |
| Title |
Continuous-trait probabilistic model for comparing multi-species functional genomic data |
| Organisms |
Chlorocebus aethiops; Pan troglodytes; Pongo pygmaeus; Homo sapiens; Nomascus leucogenys |
| Experiment type |
Other
|
| Summary |
We developed a probabilistic method to simultaneously infer genome-wide heterogeneous evolutionary states. We applied the proposed method to analyze a cross-species DNA replication timing (RT) dataset from the same cell type in five primate species. We demonstrated that the proposed model enables discovery of genomic regions with distinct evolutionary patterns of RT.
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| |
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| Overall design |
Comparing replication timing profile among 5 primate species
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| |
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| Contributor(s) |
Yang Y, Gu Q, Zhang Y, Sasaki T, Crivello J, Wang Y, O'Neill R, Gilbert DM, Ma J |
| Citation(s) |
29936186 |
| Submission date |
Mar 12, 2018 |
| Last update date |
Mar 27, 2019 |
| Contact name |
Yang Yang |
| E-mail(s) |
yy3@andrew.cmu.edu
|
| Organization name |
Carnegie Mellon University
|
| Department |
Computational Biology
|
| Street address |
5000 Forbes Ave
|
| City |
Pittsburgh |
| State/province |
PA |
| ZIP/Postal code |
15213 |
| Country |
USA |
| |
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| Platforms (5)
|
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
| GPL19148 |
Illumina HiSeq 2500 (Pan troglodytes) |
| GPL22903 |
Illumina HiSeq 2500 (Chlorocebus aethiops) |
| GPL24727 |
Illumina HiSeq 2500 (Nomascus leucogenys) |
| GPL24728 |
Illumina HiSeq 2500 (Pongo pygmaeus) |
|
| Samples (5)
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| Relations |
| BioProject |
PRJNA437983 |
| SRA |
SRP134978 |
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