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| Status |
Public on Mar 11, 2019 |
| Title |
Gene expresssion profiles in PPARalpha-Serine280 phosphorylation mutants |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
PPARalpha regulates cardiac fatty acid metabolism. GSK-3alpha phosphorylates PPARalpha at Serine 280, which increases PPARalpha transcriptional activity in cardiomyocytes.
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| |
|
| Overall design |
We transduced H9C2 cells with pDC316-YFP-PPARalpha-wild-type (WT), pDC316-YFP-PPARalpha-S280A phospho-resistant mutant, pDC316-YFP-PPARalpha-S280D phospho-mimicking mutant or pDC316-YFP alone for 2 days. Each n=2.
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| |
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| Contributor(s) |
Husain S, Nakamura M, Sadoshima J |
| Citation(s) |
30745182 |
| Submission date |
Mar 25, 2018 |
| Last update date |
Jun 17, 2019 |
| Contact name |
Michinari Nakamura |
| E-mail(s) |
nakamumi@njms.rutgers.edu
|
| Organization name |
Rutgers New Jersey Medical School
|
| Department |
Cell Biology and Molecular Medicine
|
| Lab |
Sadoshima Lab
|
| Street address |
185 South Orange Ave MSB-I543
|
| City |
Newark |
| State/province |
NJ |
| ZIP/Postal code |
07103 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL18694 |
Illumina HiSeq 2500 (Rattus norvegicus) |
|
| Samples (8)
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| Relations |
| BioProject |
PRJNA445605 |
| SRA |
SRP136414 |
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