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| Status |
Public on Mar 31, 2009 |
| Title |
Effect of corticosterone treatment on rat neuronal progenitor cells |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
|
| Summary |
Exposure to excessive glucocorticoids, which are major mediators of the stress reaction, is detrimental to brain development related to an increased risk of psychiatric disorders. However, the molecular mechanism underlying the effect of excessive glucocorticoids on the developing brain remains largely unclear. To clarify the mechanism, we examined the effects of glucocorticoids on cultured neuronal progenitor cells (NPCs) from cerebral cortices from rat embryo. We performed comparative analysis using gene expression profiling of corticosterone- or vehicle-treated NPCs. Results provide insight into the effects of glucocorticoids in regulating genetic programs important for controlling NPCs’ properties.
Keywords: expression analysis, corticosterone, neuronal progenitor, cortex
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| |
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| Overall design |
Three couples of RNA samples from corticosterone- or vehicle-treated neuronal progenitor cells were analyzed.
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| |
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| Contributor(s) |
Fukumoto K, Mayanagi T, Sobue K |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
May 16, 2008 |
| Last update date |
Jul 31, 2017 |
| Contact name |
Taira Mayanagi |
| E-mail(s) |
taira@nbiochem.med.osaka-u.ac.jp
|
| Organization name |
Osaka University Graduate School of Medicine
|
| Street address |
Yamadaoka 2-2
|
| City |
Suita |
| State/province |
Osaka |
| ZIP/Postal code |
565-0871 |
| Country |
Japan |
| |
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| Platforms (1) |
| GPL1355 |
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA106401 |
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