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| Status |
Public on Jul 05, 2018 |
| Title |
DNA methylation reprogramming after spinal nerve injury [RRBS] |
| Organism |
Rattus norvegicus |
| Experiment type |
Methylation profiling by high throughput sequencing
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| Summary |
Purpose: Nerve injury-induced hyperactivity of primary sensory neurons in the dorsal root ganglion (DRG) contributes critically to chronic pain development, but its underlying mechanisms remain incompletely understood. Chronic neuropathic pain has a clear epigenetic component, however, most studies so far have focused on histone modifications. We determined changes of DNA methylation in the rat DRG, spinal cord, and prefrontal cortex after spinal nerve ligation (SNL).
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| Overall design |
We used a rat model of neuropathic pain induced by spinal nerve ligation (SNL). We analyzed DNA methylation in dorsal root ganglia (DRG) by the RRBS method (Reduced Representation Bisulfite Sequencing).
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| Contributor(s) |
Garriga J, Laumet G, Chen S, Zhang Y, Madzo J, Issa JJ, Pan H, Jelinek J |
| Citation(s) |
29875269 |
| Submission date |
May 24, 2018 |
| Last update date |
Oct 22, 2018 |
| Contact name |
Jaroslav Jelinek |
| E-mail(s) |
jjelinek@coriell.org
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| Phone |
8567579739
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| Organization name |
Coriell Institute for Medical Research
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| Department |
Research Labs
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| Street address |
403 Haddon Avenue
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| City |
Camden |
| State/province |
NJ |
| ZIP/Postal code |
08103 |
| Country |
USA |
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| Platforms (1) |
| GPL18694 |
Illumina HiSeq 2500 (Rattus norvegicus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA472956 |
| SRA |
SRP148870 |
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