|
| Status |
Public on Jul 31, 2018 |
| Title |
mTORC1/2 inhibition re-sensitizes platinum-resistant ovarian cancer by disrupting selective translation of DNA damage and survival mRNAs |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
Other
|
| Summary |
Using platinum-resistant OVCAR-3 cells treated with the selective mTORC1/2 inhibitor INK128/MLN128, we conducted genome-wide transcription and translation studies and analyzed the effect on cell proliferation, AKT-mTOR signaling and cell survival, to determine whether carboplatin resistance involves selective mRNA translational reprogramming, and whether it is sensitive to mTORC1/2 inhibitio.n
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| |
|
| Overall design |
Polysome profiling using OVCAR-3 cells treated with INK128, carboplatin, or carboplatin + Ink128 compared to control DMSO treated cells
|
| |
|
| Contributor(s) |
Ernlund A, David-West G |
| Citation(s) |
30237852 |
| Submission date |
Jun 28, 2018 |
| Last update date |
Jul 19, 2019 |
| Contact name |
Robert J Schneider |
| E-mail(s) |
robert.schneider@nyumc.org
|
| Phone |
+1-212-263-6006
|
| Organization name |
NYU School of Medicine
|
| Department |
Microbiology
|
| Street address |
550 First Ave, MSB 238
|
| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10016 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL16686 |
[HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [transcript (gene) version] |
|
| Samples (24)
|
|
| Relations |
| BioProject |
PRJNA478373 |
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