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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Dec 31, 2019 |
| Title |
YAP activation mediates acquired resistance to ALK inhibitor in ALK rearranged non–small cell lung cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
To investigate a possible candidate for overcoming the acquired resistance to ALK-TKI, we established an in vitro model of acquired resistance to crizotinib (H3122-CR) by exposing EML4-ALK–positive H3122 lung cancer cells to increasing doses of crizotinib.
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| Overall design |
We extracted RNA using QIAGEN Rneasy mini kit from three normal H3122 cell lines, three Crizotinib resistant cells and hybridized to the Affymetrix GeneChip Array.
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| Contributor(s) |
Yun MR, Choi HM, Lee YW, Joo HS, Park CW, Choi JW, Shim HS, Soo RA, Yang JC, Lee SS, Chang H, Kim MH, Hong MH, Kim HR, Cho BC |
| Citation(s) |
31633304 |
| Submission date |
Jul 16, 2018 |
| Last update date |
Dec 31, 2019 |
| Contact name |
Mi Ran Yun |
| E-mail(s) |
FORTUNE@yuhs.ac
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| Organization name |
JE-UK Laboratory of Molecular Cancer Therapeutics
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| Department |
Yonsei Cancer Research Institute
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| Street address |
50-1 Yonsei-Ro Seodaemun-Gu
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| City |
Seoul |
| ZIP/Postal code |
KS013 |
| Country |
South Korea |
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| Platforms (1) |
| GPL16686 |
[HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [transcript (gene) version] |
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| Samples (6)
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| GSM3273064 |
Crizotinib resistance cell, biological rep1 |
| GSM3273065 |
Crizotinib resistance cell, biological rep2 |
| GSM3273066 |
Crizotinib resistance cell, biological rep3 |
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| Relations |
| BioProject |
PRJNA481361 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE117181_RAW.tar |
46.7 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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