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| Status |
Public on Jan 04, 2021 |
| Title |
Genom-wide expression study of cMoP and monocytes from murine bone marrow compared to their differentiated descendants |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
cMoP and monocytes differ in their potential to form multinucleated giant cells (MGC) in reaction to mycobacterial ligands. The aim of this expression analysis was the identification of transcriptional differences undelying the mechanisms of MGC formation.
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| Overall design |
cMoP and monocytes were collected from the bone marrow of 3 pooled Cx3cr1+/GFP C57Bl/6 mice by fluorescence-activated cell sorting. The subsets were collected directly or cultured either with M-CSF alone or additionally with lipomannan from M. smegmatis. For each subset, two replicates were purified from 2 independent litters.
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| Contributor(s) |
Lösslein A, Henneke P |
| Citation(s) |
33795674 |
| Submission date |
Jul 20, 2018 |
| Last update date |
Apr 20, 2021 |
| Contact name |
Anne Loesslein |
| E-mail(s) |
anne.loesslein@uniklinik-freiburg.de
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| Organization name |
Universität Freiburg
|
| Department |
CCI
|
| Street address |
Breisacherstr. 115
|
| City |
Freiburg |
| ZIP/Postal code |
79106 |
| Country |
Germany |
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| Platforms (1) |
| GPL17400 |
[MoGene-2_1-st] Affymetrix Mouse Gene 2.1 ST Array [transcript (gene) version] |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA482147 |
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