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| Status |
Public on Aug 03, 2018 |
| Title |
MeDIP Sequencing for 2 rat liver Samples |
| Organism |
Rattus norvegicus |
| Experiment type |
Methylation profiling by high throughput sequencing
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| Summary |
Diabetes exerts adverse effects on the initiation or progression of diabetes and metabolic syndrome of in the next generation. In past studies, limited attention has been given to the fathers’ role in shaping the metabolic landscape of offspring. Our study was designed to investigate how paternal hyperglycemia exerts an intergenerational effect in mammals as well as the underlying mechanisms. Hyperglycemia was introduced in male rats by intraperitoneally injected streptozotocin and these males were bred with healthy female rats to generate offspring. The metabolic profiles of the progeny were assessed, and DNA methylation profiles as well as gene expression related to lipid metabolism were investigated.
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| Overall design |
Examination of methylation status on the offspring of male rats treated with streptozotocin and citrate buffer,anaysis of 1 sample for each group was completed.
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| Contributor(s) |
Li X, Xiao X |
| Citation missing |
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| Submission date |
Aug 02, 2018 |
| Last update date |
Aug 04, 2018 |
| Contact name |
XINYU LI |
| E-mail(s) |
ariel_lee1983@icloud.com
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| Organization name |
The First Affiliated Hospital of Chongqing Medical University
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| Street address |
1 YOUYI ROAD
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| City |
Chongqing |
| ZIP/Postal code |
400016 |
| Country |
China |
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| Platforms (1) |
| GPL14844 |
Illumina HiSeq 2000 (Rattus norvegicus) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA484180 |
| SRA |
SRP156182 |
