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| Status |
Public on Dec 31, 2019 |
| Title |
High-throughput sequencing analysis of miRNAs expression profiles in the HCT116 colorectal cancer sublines resistant to oxaliplatin (Oxa) or 5-fluorouracil (5-FU). |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
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| Summary |
In the present study, we investigated miRNA expression changes caused by aquired chemoresistance to 5-FU or Oxa. 40 and 14 miRNAs were detected as differentially expressed in 5-fluouracil- and oxaliplatin-resistant colorectal HCT116 sublines, respectively.
Differentially expressed miRNAs determined in the present study could be applied for further development of diagnostic and therapeutic applications for colorectal cancer carcinoma resistant to 5-FU or Oxa.
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| Overall design |
miRNA expression profiles of resistant to 5-FU or Oxa colorectal carcinoma HCT116 sublines and parental HCT116 cell line were analyzed using Illumina MiSeq v2 miRNA sequencing by Illumina MiSeq system.
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| Contributor(s) |
Gasiulė S, Vilkaitis G, Ražanskas R |
| Citation(s) |
31810268 |
| Submission date |
Sep 05, 2018 |
| Last update date |
Jan 21, 2020 |
| Contact name |
Raimundas Ražanskas |
| E-mail(s) |
Raimundas.Razanskas@bti.vu.lt
|
| Organization name |
Vilnius University
|
| Department |
Institute of Biotechnology, Life Sciences Center
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| Lab |
EGIS
|
| Street address |
Sauletėkio al. 7
|
| City |
Vilnius |
| ZIP/Postal code |
LT-10257 |
| Country |
Lithuania |
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| Platforms (1) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA489366 |
| SRA |
SRP159631 |
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