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| Status |
Public on Aug 09, 2019 |
| Title |
Identify signature genes associated with nanoparticle carrying IRF5 mRNA treatment in bone marrow derrived macrophages |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
To identify signature genes associated with nanoparticles carrying IRF5 mRNA treatment on primary macrophages, we analyzed 770 genes in 19 different pathways and processes across 7 different myeloid cell types.
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| Overall design |
In the study presented here, we performed genome analysis on (1) M2-like(preincubated with IL4) and (2) M1-like macrophage standards (preincubated with MPLA), (3) IRF5-NPs and (4) eGFP-NPs treated M2-like macrophages,
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| Contributor(s) |
Coon M, Zhang F |
| Citation(s) |
31481662 |
| Submission date |
Sep 20, 2018 |
| Last update date |
Sep 11, 2019 |
| Contact name |
Matthias Stephan |
| Organization name |
Fred Hutchinson Cancer Research Institute
|
| Street address |
1100 Fairview Ave. N., Thomas Research Buildin
|
| City |
Seattle |
| State/province |
WA |
| ZIP/Postal code |
98109-9024 |
| Country |
USA |
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| Platforms (1) |
| GPL25266 |
NanoString Mouse nCounter Myeloid Innate Immunity Panel NS_Mm_Myeloid_V2.0 |
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| Samples (15)
|
| GSM3396897 |
MPLA_1: BMDM_treated with MPLA as M1 standards |
| GSM3396898 |
MPLA_2: BMDM_treated with MPLA as M1 standards |
| GSM3396899 |
MPLA_3: BMDM_treated with MPLA as M1 standards |
| GSM3396900 |
MPLA_4: BMDM_treated with MPLA as M1 standards |
| GSM3396901 |
IL4_1: BMDM_treated with IL4 as M2 standards |
| GSM3396902 |
IL4_2: BMDM_treated with IL4 as M2 standards |
| GSM3396903 |
IL4_3: BMDM_treated with IL4 as M2 standards |
| GSM3396904 |
IL4_4: BMDM_treated with IL4 as M2 standards |
| GSM3396905 |
IL4.IRF5_01: M2 macrophage treated with IRF5-NPs |
| GSM3396906 |
IL4.IRF5_02: M2 macrophage treated with IRF5-NPs |
| GSM3396907 |
IL4.IRF5_04: M2 macrophage treated with IRF5-NPs |
| GSM3396908 |
IL4.eGFP_01: M2 macrophage treated with eGFP-NPs |
| GSM3396909 |
IL4.eGFP_02: M2 macrophage treated with eGFP-NPs |
| GSM3396910 |
IL4.eGFP_03: M2 macrophage treated with eGFP-NPs |
| GSM3396911 |
IL4.eGFP_04: M2 macrophage treated with eGFP-NPs |
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| Relations |
| BioProject |
PRJNA492309 |
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