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| Status |
Public on Nov 26, 2021 |
| Title |
Expression data in bone marrow mesenchymal stromal cells derived from acute myeloid leukemia patients |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Acute myeloid leukemia (AML) is a heterogeneous clonal disorder of hematopoietic stem/progenitor cells characterized by excessive proliferation and subsequent accumulation of immature myeloid blasts, leading to impaired hematopoiesis in the bone marrow (BM). The progression of AML is closely linked to the crosstalk between leukemic cells and the BM microenvironment, in particular the mesenchymal stromal cells (MSCs).
We compared the mRNA expression profile of BM-MSCs from newly diagnosed AML patients (n=3), relapsed AML patients (n=3) and healthy donor controls (n=3)
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| Overall design |
BM-MSCs from both AML patients and healthy donors were isolated from bone marrow aspirates and hybridized on an Affymetrix Primeview Array
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| Contributor(s) |
Cheng J, Pang T, Jiang Y, Li Y |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Nov 26, 2018 |
| Last update date |
Nov 27, 2021 |
| Contact name |
Jingying Cheng |
| Organization name |
Institute of Hematology and Blood Diseases Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College
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| Street address |
288 Nanjing Road, Heping District, Tianjin
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| City |
Tianjin |
| State/province |
State... |
| ZIP/Postal code |
300020 |
| Country |
China |
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| Platforms (1) |
| GPL15207 |
[PrimeView] Affymetrix Human Gene Expression Array |
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| Samples (9)
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| GSM3488045 |
BM-MSCs from healthy donors, biological rep1 |
| GSM3488046 |
BM-MSCs from healthy donors, biological rep2 |
| GSM3488047 |
BM-MSCs from relapsed AML patients, biological rep3 |
| GSM3488048 |
BM-MSCs from healthy donors, biological rep3 |
| GSM3488049 |
BM-MSCs from newly diagnosed AML patients, biological rep1 |
| GSM3488050 |
BM-MSCs from newly diagnosed AML patients, biological rep2 |
| GSM3488051 |
BM-MSCs from newly diagnosed AML patients, biological rep3 |
| GSM3488052 |
BM-MSCs from relapsed AML patients, biological rep1 |
| GSM3488053 |
BM-MSCs from relapsed AML patients, biological rep2 |
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| Relations |
| BioProject |
PRJNA506908 |
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