|
| Status |
Public on Nov 29, 2018 |
| Title |
2-5A-Mediated mRNA Decay and Transcription Act in Concert to Reprogram Protein Synthesis during dsRNA Response |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
RNA degradation by RNase L during 2-5A-mediated decay (2-5AMD) is a conserved mammalian stress response to viral and endogenous double-stranded RNA (dsRNA). To understand this mechanism we examined 2-5AMD in human cells by spike-in RNA-seq.
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| |
|
| Overall design |
Poly-IC transfection for 0-4 h followed by poly-A pulldown and RNAseq
|
| |
|
| Contributor(s) |
Sneha R, Eliza P, Alexei K |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Nov 28, 2018 |
| Last update date |
Mar 27, 2019 |
| Contact name |
Alexei Korennykh |
| E-mail(s) |
akorenny@princeton.edu
|
| Organization name |
Princeton University
|
| Department |
Molecular Biology
|
| Lab |
Korennykh
|
| Street address |
216 Shultz Laboratory
|
| City |
Princeton |
| State/province |
New Jersey |
| ZIP/Postal code |
08540 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
|
| Samples (5)
|
|
| Relations |
| BioProject |
PRJNA507354 |
| SRA |
SRP171015 |
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