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| Status |
Public on Dec 31, 2019 |
| Title |
Identification of Potential Biomarkers for Improving the Precision of Early Detection of Steroid-induced Osteonecrosis of the Femoral Head |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Early diagnosis and prompt treatment are the key to prevent collapse and delay Steroid-induced Osteonecrosis of the Femoral Head(SONFH) progression.The aim of this study was to identify potential biomarkers for the diagnosis of SONFH, so to improve the efficiency of early diagnosis.
Microarray analysis based on the 30 SONFH patients and 10 non-SONFH patients(following steroid administration) was performed to screen SONFH-related genes.
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| Overall design |
The aim of this study was to identify potential biomarkers for the diagnosis of SONFH. The gene expression profile was detected by microarray analysis based on the 30 SONFH patients and 10 non-SONFH patients. Then, a list of candidate gene biomarkers of SONFH were identified by integrating differential expression data analysis and gene signal transduction network analysis.
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| Contributor(s) |
Zhang Y |
| Citation(s) |
37313692 |
| Submission date |
Dec 10, 2018 |
| Last update date |
Sep 08, 2023 |
| Contact name |
Yanqiong Zhang |
| E-mail(s) |
yqzhang@icmm.ac.cn
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| Organization name |
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences
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| Street address |
No 16, Nanxiaojie, Dongzhimennei
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| City |
Beijing |
| ZIP/Postal code |
100700 |
| Country |
China |
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| Platforms (1) |
| GPL15207 |
[PrimeView] Affymetrix Human Gene Expression Array |
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| Samples (40)
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| GSM3507251 |
Peripheral serum, control group, patient 1 |
| GSM3507252 |
Peripheral serum, control group, patient 2 |
| GSM3507253 |
Peripheral serum, control group, patient 3 |
| GSM3507254 |
Peripheral serum, control group, patient 4 |
| GSM3507255 |
Peripheral serum, control group, patient 5 |
| GSM3507256 |
Peripheral serum, control group, patient 6 |
| GSM3507257 |
Peripheral serum, control group, patient 7 |
| GSM3507258 |
Peripheral serum, control group, patient 8 |
| GSM3507259 |
Peripheral serum, control group, patient 9 |
| GSM3507260 |
Peripheral serum, control group, patient 10 |
| GSM3507261 |
Peripheral serum, disease group, patient 1 |
| GSM3507262 |
Peripheral serum, disease group, patient 2 |
| GSM3507263 |
Peripheral serum, disease group, patient 3 |
| GSM3507264 |
Peripheral serum, disease group, patient 4 |
| GSM3507265 |
Peripheral serum, disease group, patient 5 |
| GSM3507266 |
Peripheral serum, disease group, patient 6 |
| GSM3507267 |
Peripheral serum, disease group, patient 7 |
| GSM3507268 |
Peripheral serum, disease group, patient 8 |
| GSM3507269 |
Peripheral serum, disease group, patient 9 |
| GSM3507270 |
Peripheral serum, disease group, patient 10 |
| GSM3507271 |
Peripheral serum, disease group, patient 11 |
| GSM3507272 |
Peripheral serum, disease group, patient 12 |
| GSM3507273 |
Peripheral serum, disease group, patient 13 |
| GSM3507274 |
Peripheral serum, disease group, patient 14 |
| GSM3507275 |
Peripheral serum, disease group, patient 15 |
| GSM3507276 |
Peripheral serum, disease group, patient 16 |
| GSM3507277 |
Peripheral serum, disease group, patient 17 |
| GSM3507278 |
Peripheral serum, disease group, patient 18 |
| GSM3507279 |
Peripheral serum, disease group, patient 19 |
| GSM3507280 |
Peripheral serum, disease group, patient 20 |
| GSM3507281 |
Peripheral serum, disease group, patient 21 |
| GSM3507282 |
Peripheral serum, disease group, patient 22 |
| GSM3507283 |
Peripheral serum, disease group, patient 23 |
| GSM3507284 |
Peripheral serum, disease group, patient 24 |
| GSM3507285 |
Peripheral serum, disease group, patient 25 |
| GSM3507286 |
Peripheral serum, disease group, patient 26 |
| GSM3507287 |
Peripheral serum, disease group, patient 27 |
| GSM3507288 |
Peripheral serum, disease group, patient 28 |
| GSM3507289 |
Peripheral serum, disease group, patient 29 |
| GSM3507290 |
Peripheral serum, disease group, patient 30 |
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| Relations |
| BioProject |
PRJNA509241 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE123568_RAW.tar |
71.8 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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