|
| Status |
Public on Dec 18, 2019 |
| Title |
BACH1 alters the expression of EMT-related genes to promote metastasis in pancreatic cancer [RNA-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
BTB and CNC homology 1 (BACH1) has been implicated in RAS-driven tumor formation. We focused on the role of BACH1 in Pancreatic ductal adenocarcinoma (PDAC), more than 90% of which have KRAS mutation. BACH1 directly or indirectly repressed the expression of genes for epithelial cell adhesion in AsPC-1 cells and SW1990. Knockdown and overexpression of BACH1 in PDAC cell lines indicated that BACH1 promoted cell migration and invasion in part by reducing E-cadherin expression.
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| |
|
| Overall design |
Search of BACH1 target genes in pancreatic cancer cells
|
| |
|
| Contributor(s) |
Matsumoto M, Sato M, Funayama R, Nakayama K, Igarashi K |
| Citation(s) |
31919242 |
| Submission date |
Dec 27, 2018 |
| Last update date |
Mar 18, 2020 |
| Contact name |
Mitsuyo Matsumoto |
| E-mail(s) |
mitsuyo.matsumoto.d5@tohoku.ac.jp
|
| Organization name |
Tohoku university school of medicine
|
| Department |
Biochemistry
|
| Street address |
2-1 Seiryo-machi Aoba-ku
|
| City |
Sendai |
| ZIP/Postal code |
980-8575 |
| Country |
Japan |
| |
|
| Platforms (1) |
| GPL17303 |
Ion Torrent Proton (Homo sapiens) |
|
| Samples (12)
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| This SubSeries is part of SuperSeries: |
| GSE124408 |
BACH1 alters the expression of EMT-related genes to promote metastasis in pancreatic cancer |
|
| Relations |
| BioProject |
PRJNA511965 |
| SRA |
SRP174544 |
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