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| Status |
Public on Dec 28, 2018 |
| Title |
Diminished OPA1 expression and impaired mitochondrial morphology and homeostasis in Aprataxin-deficient cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Ataxia with oculomotor apraxia type 1 (AOA1) is an early onset progressive spinocerebellar ataxia caused by mutation in aprataxin (APTX). Here we use RNA-seq to identify genes that are affected by APTX-KO, APTX overexpression, and APTX mutant, thus contributes to understadning the mechanisms underlying AOA1 pathlogy.
Published: https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkz083/5319145
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| |
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| Overall design |
Examination the chages of gene expressions in APTX proficient and APTX deficienc cells.
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| Web link |
https://doi.org/10.1093/nar/gkz083
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| |
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| Contributor(s) |
Zheng J, Croteau DL |
| Citation(s) |
30986824 |
| Submission date |
Dec 27, 2018 |
| Last update date |
Apr 26, 2019 |
| Contact name |
Jin Zheng |
| E-mail(s) |
zhj821107@icloud.com
|
| Phone |
+4550245870
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| Organization name |
University of Copenhagen
|
| Street address |
3b Blegdamsvej
|
| City |
Copenhagen |
| ZIP/Postal code |
2200 |
| Country |
Denmark |
| |
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| Platforms (1) |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA511981 |
| SRA |
SRP174572 |
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