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| Status |
Public on Feb 14, 2019 |
| Title |
Long noncoding RNA MALAT1 activates HIV-1 infection by detaching polycomb repressive complex 2 from binding to the promoter of long terminal repeat for mediating epigenetic silencing |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
|
| Summary |
Accumulating data have emphasized the critical role of long noncoding RNAs (lncRNAs) in regulating HIV-1 replication. LncRNAs may repress or active HIV-1 replication and latency through regulating different cellular machineries. Our RNA-Sequencing (RNA-Seq) revealed the up-regulation of MALAT1 (metastasis-associated lung adenocarcinoma transcript 1), a lncRNA being mainly described in cancer cells that associates with cancer pathogenesis, in HIV-1 infected CD4+ T cells
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| Overall design |
HIV-1NL4-3-infected and uninfected CD4+ T cells, sequenced on Hiseq X10 sequencer (Illumina)
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| Contributor(s) |
Hou W, Qu D |
| Citation(s) |
30788509 |
| Submission date |
Dec 28, 2018 |
| Last update date |
Apr 17, 2019 |
| Contact name |
LI LI |
| E-mail(s) |
1805913496@qq.com
|
| Organization name |
wuhan university school of basic medical sciences
|
| Street address |
185 Donghu Road
|
| City |
Wuhan |
| State/province |
Hubei |
| ZIP/Postal code |
430071 |
| Country |
China |
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| Platforms (1) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA512098 |
| SRA |
SRP174643 |
