|
| Status |
Public on May 22, 2020 |
| Title |
A cancer stem cell hierarchy based on differential ribosomal RNA and protein synthesis capacities [POLR1A] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Ribosomal RNA (rRNA) transcription and protein synthesis are heterogeneously regulated in colorectal tumors and are gradually shut down during cell differentiation. Cancer stem cell hierarchy and tumor growth is defined by a tumor cell population that displays elevated rRNA and protein synthesis.
|
| |
|
| Overall design |
Tumor cells expressing different levels of POLR1A were isolated from subcutaneous patient derived xenografts
|
| |
|
| Contributor(s) |
Morral C, Batlle E |
| Citation(s) |
32396863 |
| Submission date |
Jan 17, 2019 |
| Last update date |
Aug 24, 2020 |
| Contact name |
Antoni Berenguer-LLergo |
| E-mail(s) |
aberenguerl@tauli.cat
|
| Organization name |
Parc Taulí Research and Innovation Institute (I3PT)
|
| Department |
A8G2 Group - Rheumatology Service
|
| Street address |
Parc del Taulí, 1
|
| City |
Sabadell |
| State/province |
Barcelona |
| ZIP/Postal code |
08208 |
| Country |
Spain |
| |
|
| Platforms (1) |
| GPL15207 |
[PrimeView] Affymetrix Human Gene Expression Array |
|
| Samples (4)
|
| GSM3566870 |
POLR1A high epithelium tumor cells from patient derived xenograft (1438) |
| GSM3566871 |
POLR1A low epithelium tumor cells from patient derived xenograft (1439) |
| GSM3566872 |
POLR1A high epithelium tumor cells from patient derived xenograft (1440) |
| GSM3566873 |
POLR1A low epithelium tumor cells from patient derived xenograft (1441) |
|
| This SubSeries is part of SuperSeries: |
| GSE125232 |
A cancer stem cell hierarchy based on differential ribosomal RNA and protein synthesis capacities |
|
| Relations |
| BioProject |
PRJNA515613 |
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