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| Status |
Public on Mar 31, 2019 |
| Title |
Whole Sequencing Of The Mitochondrial Genome Of Breast Tumor Tissue In Mexican-Mestizo Postmenopausal Women, With Different Body Mass Index |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by genome tiling array
|
| Summary |
Mitochondrial and oxidative stress have been related to obesity and breast cancer, and this cancer is more frequent and more aggressive in postmenopausal women with obesity.
To investigate if Mexican-Mestizo postmenopausal women with breast cancer and obesity presented different somatic mutations in the mitochondrial DNA (mtDNA) when compared to women with normal body mass index.
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| Overall design |
The whole mtDNA sequence was determined by MitoChip v2.0 mitochondrial resequencing array, and the analysis of data was performed using the GeneChip Sequence Analysis Software. Mitochondrial tumor DNA sequence was compared with matched leukocyte mtDNA sequence.
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| Contributor(s) |
Adams-Reyes N, Coral-Vázquez RM, Méndez JP, Tenorio A, Znteno JC, Villegas-Ruiz V, Canto P |
| Citation(s) |
31448780 |
| Submission date |
Jan 28, 2019 |
| Last update date |
Jun 29, 2022 |
| Contact name |
Nishi Alan Adams-Reyes |
| Phone |
2223411316
|
| Organization name |
Universidad Nacional Autónoma de México
|
| Department |
Faculty of Medicine
|
| Lab |
Obesity Research Unit
|
| Street address |
AV. UNIVERSIDAD 3000
|
| City |
Ciudad de México |
| State/province |
Cuidad de México |
| ZIP/Postal code |
04510 |
| Country |
Mexico |
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| Platforms (1) |
| GPL10983 |
[Mitochip_2] Affymetrix Human Mitochondrial Resequencing Array 2.0 |
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| Samples (12)
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| GSM3582019 |
Blood sample_patient with normal body mass index_non-hereditary breast cancer (Patient 1; control) |
| GSM3582020 |
Tumor breast tissue_patient with a normal body mass index_non-hereditary breast cancer (Patient 1) |
| GSM3582021 |
Blood sample_patient with normal body mass index_non-hereditary breast cancer (Patient 2; control) |
| GSM3582022 |
Tumor breast tissue_patient with a normal body mass index_non-hereditary breast cancer (Patient 2) |
| GSM3582023 |
Blood sample_patient with normal body mass index_non-hereditary breast cancer (Patient 3; control) |
| GSM3582024 |
Tumor breast tissue_patient with a normal body mass index_non-hereditary breast cancer (Patient 3) |
| GSM3582025 |
Blood sample of patient with obesity_non-hereditary breast cancer (Patient 4; control) |
| GSM3582026 |
Tumor breast tissue_patient with obesity_non-hereditary breast cancer (Patient 4) |
| GSM3582027 |
Blood sample of patient with obesity_non-hereditary breast cancer (Patient 5; control) |
| GSM3582028 |
Tumor breast tissue_patient with obesity_non-hereditary breast cancer (Patient 5) |
| GSM3582029 |
Blood sample of patient with obesity_non-hereditary breast cancer (Patient 6; control) |
| GSM3582030 |
Tumor breast tissue_patient with obesity_non-hereditary breast cancer (Patient 6) |
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| Relations |
| BioProject |
PRJNA517538 |
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