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| Status |
Public on Apr 25, 2019 |
| Title |
Gene expression analysis of vascular pathophysiology related to anti-TNF treatment in rheumatoid arthritis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Our goal was to find correlations between gene expression patterns and impaired vascular pathophysiolgy in rheumatoid arthritis
Patients with rheumatoid arthritis were recruited and venous blood samples were collected, then peripheral blood mononuclear cells were separated. After RNA isoltaion, we used Affymetrix PrimeView arrays to obtain whole gene expression data.
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| Overall design |
Samples of 19 patients with rheumatoid arthritis were examined. Sub-groups based the following clinical parameters flow-mediated vasodilation (FMD), pulse-wave velocity (PWV) and common carotid intima-media thickness (IMT) status were created and differentially expressed genes were determined in each sub-groups.
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| Contributor(s) |
Bessenyei T, Végh E, Hamar A, Pusztai A, Váncsa A, Bodnár N, Szamosi S, Csumita M, Kerekes G, Szabó Z, Nagy Z, Szücs G, Szántó S, Zahuczky G, Nagy L, Szekanecz Z |
| Citation(s) |
30987671 |
| Submission date |
Feb 12, 2019 |
| Last update date |
Apr 25, 2019 |
| Contact name |
Szilard Poliska |
| E-mail(s) |
poliska@dote.hu
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| Phone |
+3652416432
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| Organization name |
University of Debrecen
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| Department |
Biochemistry and Molecular Biology
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| Lab |
Nuclear Hormone Receptor Research Laboratory
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| Street address |
Egyetem ter 1.
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| City |
Debrecen |
| ZIP/Postal code |
H-4012 |
| Country |
Hungary |
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| Platforms (1) |
| GPL15207 |
[PrimeView] Affymetrix Human Gene Expression Array |
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| Samples (19)
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| Relations |
| BioProject |
PRJNA522008 |
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