|
| Status |
Public on Mar 22, 2019 |
| Title |
Targeting IDH1 as a pro-senescent therapy in high-grade serous ovarian cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We found that targeting IDH1 in HGSC induces senescence by altering the repressive histone landscape of E2F target genes
|
| |
|
| Overall design |
Ovcar3 cells were infected with control or shIDH1. Cells were selected in 3ug/mL puromycin for 7 days. RNA was isolated and RNA-seq was performed comparing control and knockdown RNA.
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| |
|
| Contributor(s) |
Dahl ES, Buj R, Leon KE, Newell JM, Imamura Y, Bitler BG, Snyder NW, Aird KM |
| Citation(s) |
31110157 |
| Submission date |
Mar 21, 2019 |
| Last update date |
Jun 20, 2019 |
| Contact name |
Yuka Imamura Kawasawa |
| E-mail(s) |
yui102@psu.edu
|
| Organization name |
Penn State University
|
| Department |
College of Medicine, Pharmacology
|
| Street address |
500 University Dr.
|
| City |
Hershey |
| State/province |
PA |
| ZIP/Postal code |
17033 |
| Country |
USA |
| |
|
| Platforms (1) |
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| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA528523 |
| SRA |
SRP189116 |
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